CT and NG clearance at T2 in urine, vaginal swabs, anorectal swabs and oropharyngeal swabs, including sensitivity analyses using different scenarios
| Clearance | Sensitivity analyses (restricting the main population to subgroups) | ||||||||||
| MSM | Heterosexual men | Women | Total | No antibiotics between T1 and T2* | Interval <14 days | No sexual exposure* | |||||
| % (n/N) | % (n/N) | % (n/N) | % (n/N) | 95% CI | % (n) | Clearance % (n/N) | % (n) | Clearance % (n/N) | % (n) | Clearance % (n/N) | |
| Chlamydia | |||||||||||
| Urine | 0 (0/11) | 10.1 (10/99) | NA | 9.0 (10/110) | 4.4 to 16.9 | 98.2 (108) | 9.3 (10/108) | 77.3 (85) | 9.4 (8/85) | 68.2 (75) | 9.3 (7/75) |
| Vaginal | NA | NA | 6.8 (20/292) | 6.8 (20/292) | 4.2 to 10.4 | 77.7 (227) | 6.2 (14/227) | 86.0 (251) | 7.6 (19/251) | 62.0 (181) | 7.2 (13/181) |
| Anorectal† | 4.0 (1/25) | NA | 18.4 (7/38) | 12.7 (8/63) | 5.7 to 23.5 | 69.8 (44) | 11.4 (5/44) | 87.3 (55) | 10.9 (6/55) | 55.6 (35) | 17.1 (6/35) |
| Oropharyngeal‡ | 80.0 (4/5) | NA | 0 (0/2) | 57.1 (4/7)§ | 18.4 to 90.1 | 85.7 (6) | 50.0 (3/6) | 85.7 (6) | 66.7 (4/6) | 57.1 (4) | 100 (2/2) |
| Gonorrhoea | |||||||||||
| Urine‡ | 66.7 (2/3) | 0 (0/3) | NA | 33.3 (2/6) | 4.3 to 77.7 | 66.7 (4) | 25.0 (1/4) | 100 (6) | 33.3 (2/6) | 83.3 (5) | 40.0 (2/5) |
| Vaginal‡ | NA | NA | 28.6 (2/7) | 28.6 (2/7) | 3.7 to 80.0 | 85.7 (6) | 33.3 (2/6) | 85.7 (6) | 16.7 (1/6) | 42.9 (3) | 0 (0/3) |
| Anorectal‡ | 22.2 (2/9) | NA | 0 (0/1) | 20.0 (2/10) | 2.5 to 55.6 | 66.0 (6) | 0 (0/6) | 100 (10) | 20.0 (2/10) | 70.0 (7) | 14.3 (1/7) |
| Oropharyngeal† | 30.8 (4/13) | NA | 22.2 (2/9) | 27.3 (6/22) | 10.7 to 50.2 | 72.7 (16) | 18.8 (3/16) | 72.7 (16) | 31.3 (5/16) | 68.2 (15) | 33.3 (5/15) |
*Anorectal CT clearance and oropharyngeal NG clearance were not statistically significantly different between MSM and women (p=0.09 and p=0.66, respectively).
†Low absolute numbers (n≤10).
‡Consultations with a missing questionnaire between T1 and T2 were excluded for analyses (n=59).
§P<0.001 compared with urine.
CT, Chlamydia trachomatis; MSM, men who have sex with men; NA, not assessed; NG, Neisseria gonorrhoeae.