Univariable analysis of predictors of incident anal HRHPV in the Study of the Prevention of Anal Cancer
| Objectives | N | PY | Incidence (per 100 PY) | HR | 95% CI | P value |
| Age (years) | 0.613* | |||||
| 35–44 | 124 | 3426.0 | 3.6 | 1 | – | |
| 45–54 | 205 | 6640.1 | 3.1 | 0.87 | 0.64 to 1.18 | |
| 55–64 | 155 | 4056.6 | 3.8 | 1.33 | 0.95 to 1.85 | |
| >65 | 48 | 2139.7 | 2.2 | 0.80 | 0.52 to 1.24 | |
| HIV status | <0.001 | |||||
| Negative | 312 | 10 889.9 | 2.9 | 1 | – | |
| Positive | 220 | 5372.5 | 4.1 | 1.59 | 1.25 to 2.02 | |
| Sexual position preference for anal intercourse | 0.014* | |||||
| Mostly insertive | 155 | 5577.1 | 2.8 | 1 | – | |
| Versatile | 254 | 7164.5 | 3.5 | 1.32 | 1.00 to 1.75 | |
| Mostly receptive | 118 | 3428.3 | 3.4 | 1.45 | 1.06 to 1.99 | |
| RAI with and without condom use in the last 6 months | <0.001* | |||||
| No RAI | 115 | 5597.4 | 2.1 | 1 | ||
| Condom protected RAI only | 103 | 2849.1 | 3.6 | 1.84 | 1.31 to 2.58 | |
| Any condomless RAI | 311 | 7701.6 | 4.0 | 1.90 | 1.44 to 2.50 | |
| Number of RAI partners with a condom in the last 6 months | <0.001* | |||||
| 0 | 175 | 8166.6 | 2.1 | 1 | – | |
| 1 | 102 | 3034.9 | 3.4 | 1.69 | 1.23 to 2.33 | |
| 2–5 | 172 | 3275.1 | 5.3 | 2.69 | 2.04 to 3.54 | |
| >5 | 80 | 1671.4 | 4.8 | 2.23 | 1.57 to 3.16 | |
| Number of RAI partners without a condom in the last 6 months | <0.001* | |||||
| 0 | 218 | 8446.4 | 2.6 | 1 | – | |
| 1 | 143 | 4650.2 | 3.1 | 1.12 | 0.85 to 1.47 | |
| ≥2 | 168 | 3051.4 | 5.5 | 2.07 | 1.57 to 2.73 | |
| Insertive anal intercourse with condom in the last 6 months | 0.061* | |||||
| Never | 264 | 9113.6 | 2.9 | 1 | – | |
| Occasionally | 182 | 5118.2 | 3.6 | 1.17 | 0.90 to 1.52 | |
| Often | 83 | 1916.3 | 4.3 | 1.36 | 0.96 to 1.92 | |
| Insertive anal intercourse without condom in the last 6 months | 0.547* | |||||
| Never | 259 | 8810.9 | 2.9 | 1 | – | |
| Occasionally | 183 | 4940.3 | 3.7 | 1.23 | 0.95 to 1.60 | |
| Often | 87 | 2396.8 | 3.6 | 1.01 | 0.74 to 1.38 | |
| Rimmed in the last 6 months | 0.002 | |||||
| No | 139 | 5638.6 | 2.5 | 1 | – | |
| Yes | 390 | 10 509.5 | 3.7 | 1.50 | 1.16 to 1.93 | |
| Receptive fingering in the last 6 months | 0.030 | |||||
| No | 153 | 5694.2 | 2.7 | 1 | – | |
| Yes | 376 | 10 453.9 | 3.6 | 1.32 | 1.03 to 1.70 | |
| Receptive fisting in the last 6 months | 0.129 | |||||
| No | 453 | 14 436.7 | 3.1 | 1 | – | |
| Yes | 76 | 1688.8 | 4.5 | 1.34 | 0.92 to 1.95 | |
| Shelved drugs in the last 6 months | 0.815 | |||||
| No | 509 | 15 699.7 | 3.2 | 1 | – | |
| Yes | 20 | 448.3 | 4.5 | 1.09 | 0.53 to 2.24 | |
| Receptive use of toys in the last 6 months | 0.001 | |||||
| No | 333 | 11 258.8 | 3.0 | 1 | – | |
| Yes | 196 | 4829.7 | 4.1 | 1.49 | 1.17 to 1.91 | |
| Non-intercourse receptive sexual practices combined (rimming, fingering and use of toys) | 0.015 | |||||
| No | 100 | 3983.6 | 2.5 | 1 | – | |
| Yes | 432 | 12 278.8 | 3.5 | 1.41 | 1.07 to 1.85 | |
*P value for trend.
HRHPV, high-risk human papillomavirus; PY, person-years; RAI, receptive anal intercourse.