Table 3

Risk ratios of neurotoxicities including only efavirenz RCTs

Adverse eventDrug(s)Risk ratio95% CIP valueStudies includedI2 %
DepressionDolutegravir0.860.56 to 1.330.511N/A
Rilpivirine1.080.80 to 1.480.22433
Combined1.020.8 to 1.480.88521
AnxietyDolutegravir0.90.58 to 1.410.661N/A
Rilpivirine0.680.35 to 1.340.27375
Combined0.750.48 to 1.180.21464
InsomniaDolutegravir1.070.38 to 2.990.89245
Rilpivirine10.71 to 1.411462
Combined1.060.78 to 1.440.71662
DizzinessDolutegravir0.280.21 to 0.38<0.0000120
Rilpivirine0.350.28 to 0.43<0.0000150
Combined0.330.28 to 0.39<0.00001715.3
Suicidal behaviourDolutegravir0.830.26 to 2.610.7420
Rilpivirine1.320.36 to 4.80.67317
Combined10.45 to 2.220.650
  • N/A, not applicable; RCTs, randomised controlled trials.