Table 2

Risk ratios of neurotoxicities excluding efavirenz RCTs

Adverse eventDrug(s)Risk ratio95% CIP valueStudies includedI2 %
DepressionDolutegravir1.260.96 to 1.650.0980
Dolutegravir/rilpivirine2.821.12 to 7.070.021N/A
Combined1.341.04 to 1.740.0290
AnxietyDolutegravir0.990.72 to 1.360.95712
Dolutegravir/rilpivirine1.370.56 to 3.380.491N/A
Combined1.020.77 to 1.350.9184
InsomniaDolutegravir1.170.88 to 1.540.28926
Dolutegravir/rilpivirine1.690.78 to 3.660.181N/A
Combined1.20.93 to 1.560.161023
DizzinessDolutegravir1.120.85 to 1.480.4360
Dolutegravir/rilpivirine20.921.23 to 356.030.041N/A
Combined1.230.94 to 1.620.14722
Suicidal behaviourDolutegravir1.010.55 to 1.860.9885
Dolutegravir/rilpivirine2.990.31 to 28.630.341N/A
Combined1.080.6 to 1.940.893
  • N/A, not applicable; RCTs, randomised controlled trials.