Population type | Outcome measures | Samples | Proportion of HSV-2 isolation (%) | Pooled proportion of HSV-2 isolation (%) | Heterogeneity measures | |||

Total N | Total N | Range | Median | Mean (95% CI) | Q*(P value) | I²† (%) (95% CI) | Prediction interval‡ (%) | |

Patients with GUD | 7 | 603 | 0.0–77.7 | 50.9 | 41.4 (18.9 to 67.0) | 184.5 (<0.001) | 96.7 (95.0 to 97.9) | 0.0–100 |

Patients with genital herpes | 10 | 278 | 71.5–100 | 90.1 | 91.1 (82.7 to 97.2) | 31.3 (<0.001) | 71.2 (45.2 to 84.9) | 58.3–100 |

*Q: the Cochran’s Q statistic is a measure assessing the existence of heterogeneity in pooled outcome measures, here proportions of HSV-2 virus isolation in GUD and in genital herpes.

†I² a measure assessing the magnitude of between-study variation that is due to true differences in proportions of HSV-2 virus isolation across studies rather than sampling variation.

‡Prediction interval: a measure quantifying the distribution 95% interval of true proportions of HSV-2 virus isolation around the estimated pooled mean.

GUD, genital ulcer disease; HSV-2, herpes simplex virus type 2.