Table 2

Effect of chemsex at baseline on time to first STI diagnosis among pre-exposure prophylaxis (PrEP) users in the l’Actuel PrEP Cohort (2013–2020)

Outcome# of eventsCrude modelsAdjusted models
HRHR
Model with chemsex only
 Gonorrhoea or chlamydia6141.40 (1.18 to 1.67)1.32 (1.10 to 1.57)
 Gonorrhoea4101.70 (1.38 to 2.08)1.59 (1.28 to 1.97)
 Chlamydia3691.15 (0.92 to 1.45)1.07 (0.84 to 1.36)
Model with chemsex and polysubstance use
 Gonorrhoea or chlamydia614
 No chemsexReference
 Chemsex1.20 (0.94 to 1.53)1.12 (0.87 to 1.43)
 Polysubstance use1.61 (1.30 to 1.99)1.51 (1.21 to 1.89)
  • Created by the authors.

  • Models adjusted for age, education, income, PrEP regimen at baseline and year of entry into the cohort (all categorical).

  • Results were qualitatively identical when the models were restricted to cisgender gbMSM (online supplemental table 3).

  • gbMSM, gay, bisexual and other men who have sex with men.