Description and comparison of demographic, behavioural and social characteristics of respondents who ‘discontinued PrEP after the lockdown’ and respondents ‘currently using PrEP’ and factors associated with ‘discontinued PrEP after the lockdown’ versus ‘currently using PrEP’: univariable model among ERAS-COVID-19 respondents (n=946)
| Current PrEP user after the lockdown n=800 (84.6%) | Former PrEP user (discontinued PrEP after the lockdown) n=146 (15.4%) | Total n=946 | Univariable model (n=946) | |||
| n (%) | n (%) | n (%) | P value | OR (95% CI) | P value | |
| Age, median (IQR) (for one-unit increase) | 36 (30–44) | 33 (26–38) | 35 (29–44) | <0.001 | 0.95 (0.94 to 0.97) | <0.001 |
| Place of birth | 0.124 | |||||
| Metropolitan France and French overseas departments and territories | 718 (89.7) | 137 (93.8) | 855 (90.4) | 1.00 | ||
| Outside of France | 82 (10.3) | 9 (6.2) | 91 (9.6) | 0.58 (0.27 to 1.17) | 0.128 | |
| Education level | 0.921 | |||||
| Secondary education or lower (high school or lower) | 118 (14.8) | 22 (15.1) | 140 (14.8) | 1.00 | ||
| Higher education (post high school) | 682 (85.2) | 124 (84.9) | 806 (85.2) | 0.98 (0.60 to 1.60) | 0.921 | |
| Reside in a city of more than 100 000 inhabitants | 0.610 | |||||
| No | 300 (37.5) | 58 (39.7) | 358 (37.8) | 1.00 | ||
| Yes | 500 (62.5) | 88 (60.3) | 588 (62.2) | 0.91 (0.63 to 1.31) | 0.610 | |
| Single (relationship status) | 0.244 | |||||
| No | 380 (47.5) | 77 (52.7) | 457 (48.3) | 1.00 | ||
| Yes | 420 (52.5) | 69 (47.3) | 489 (51.7) | 0.81 (0.57 to 1.15) | 0.245 | |
| Employment status before the lockdown | <0.001 | |||||
| Not employed | 117 (14.6) | 41 (28.1) | 158 (16.7) | 1.00 | ||
| Employed | 683 (85.4) | 105 (71.9) | 788 (83.3) | 0.44 (0.29 to 0.66) | <0.001 | |
| No change in the working conditions during the lockdown | 0.013 | |||||
| No | 529 (66.1) | 81 (55.5) | 610 (64.5) | 1.00 | ||
| Yes | 271 (33.9) | 65 (44.5) | 336 (35.5) | 1.57 (1.10 to 2.24) | 0.014 | |
| Decline in financial situation during the lockdown | 0.064 | |||||
| No | 616 (77.0) | 102 (69.9) | 718 (75.9) | 1.00 | ||
| Yes | 184 (23.0) | 44 (30.1) | 228 (24.1) | 1.44 (0.98 to 2.13) | 0.065 | |
| Lived with a stable partner during the lockdown | 0.150 | |||||
| No | 498 (62.2) | 100 (68.5) | 598 (63.2) | 1.32 (0.90 to 1.92) | 0.151 | |
| Yes | 302 (37.8) | 46 (31.5) | 348 (36.8) | 1.00 | ||
| Suffered from loneliness during the lockdown | 0.036 | |||||
| No | 647 (80.9) | 107 (73.3) | 754 (79.7) | 1.00 | ||
| Yes | 153 (19.1) | 39 (26.7) | 192 (20.3) | 1.54 (1.03 to 2.31) | 0.037 | |
| Generalised anxiety (GAD-7) during the lockdown | 0.036 | |||||
| No anxiety | 331 (41.4) | 43 (29.4) | 374 (39.5) | 1.00 | ||
| Mild anxiety | 330 (41.2) | 68 (46.6) | 398 (42.1) | 1.59 (1.05 to 2.39) | 0.028 | |
| Moderate anxiety | 101 (12.6) | 27 (18.5) | 128 (13.5) | 2.06 (1.21 to 3.50) | 0.008 | |
| Severe anxiety | 38 (4.8) | 8 (5.5) | 46 (4.9) | 1.62 (0.71 to 3.70) | 0.252 | |
| Increased alcohol consumption during the lockdown | 0.334 | |||||
| No | 400 (50.0) | 64 (43.8) | 464 (49.0) | 1.00 | ||
| Yes | 231 (28.9) | 50 (34.3) | 281 (29.7) | 1.35 (0.90 to 2.03) | 0.142 | |
| Not concerned (no alcohol consumption prior to lockdown) | 169 (21.1) | 32 (21.9) | 201 (21.3) | 1.18 (0.75 to 1.88) | 0.474 | |
| Increased consumption of psychoactive drugs during the lockdown | 0.002 | |||||
| No | 293 (36.6) | 32 (21.9) | 325 (34.4) | 1.00 | ||
| Yes | 75 (9.4) | 17 (11.7) | 92 (9.7) | 2.08 (1.09 to 3.94) | 0.025 | |
| Not concerned (no drug consumption prior to lockdown) | 432 (54.0) | 97 (66.4) | 529 (55.9) | 2.06 (1.34 to 3.15) | 0.001 | |
| Psychological distress in the past month | 0.020 | |||||
| No | 545 (68.1) | 85 (58.2) | 630 (66.6) | 1.00 | ||
| Yes | 255 (31.9) | 61 (41.8) | 316 (33.4) | 1.53 (1.07 to 2.20) | 0.020 | |
| Tested at least once for HIV or STI during the lockdown (if HIV tested in the last 12 months) | 0.022 | |||||
| Yes, HIV and/or STI | 397 (50.5) | 54 (39.7) | 451 (48.9) | 1.00 | ||
| No, ‘didn’t know where to go’ or ‘preferred to wait’ | 268 (34.1) | 50 (36.8) | 318 (34.5) | 1.37 (0.91 to 2.08) | 0.135 | |
| No, other reason | 121 (15.4) | 32 (23.5) | 153 (16.6) | 1.94 (1.20 to 3.15) | 0.007 | |
| Tested at least once for HIV or STI since the end of the lockdown (if HIV tested in the last 12 months) | <0.001 | |||||
| Yes, HIV and/or STI | 552 (70.2) | 44 (32.3) | 596 (64.6) | 1.00 | ||
| No, ‘didn’t know where to go’ or ‘preferred to wait’ | 79 (10.1) | 28 (20.6) | 107 (11.6) | 4.45 (2.62 to 7.55) | <0.001 | |
| No, other reason | 155 (19.7) | 64 (47.1) | 219 (23.8) | 5.18 (3.39 to 7.91) | <0.001 | |
| PrEP regimen before the lockdown | <0.001 | |||||
| Daily | 442 (55.2) | 46 (31.5) | 488 (51.6) | 1.00 | ||
| On demand | 358 (44.8) | 100 (68.5) | 458 (48.4) | 2.68 (1.84 to 3.91) | <0.001 | |
| Number of male sexual partners in the previous 6 months | <0.001 | |||||
| 0–1 | 30 (3.7) | 35 (24.0) | 65 (6.9) | 13.87 (7.77 to 24.73) | <0.001 | |
| 2–9 | 259 (32.4) | 68 (46.6) | 327 (34.6) | 3.12 (2.07 to 4.70) | <0.001 | |
| 10 or more | 511 (63.9) | 43 (29.4) | 554 (58.5) | 1.00 | ||
| Limited the number of sexual partners during the lockdown | 0.011 | |||||
| No | 527 (66.5) | 109 (77.3) | 636 (68.2) | 1.00 | ||
| Yes | 265 (33.5) | 32 (22.7) | 297 (31.8) | 0.58 (0.38 to 0.89) | 0.012 | |
| Sexual partners during the lockdown | 0.006 | |||||
| No | 409 (54.4) | 72 (68.6) | 481 (56.1) | 1.00 | ||
| Yes | 343 (45.6) | 33 (31.4) | 376 (43.9) | 0.55 (0.35 to 0.85) | 0.007 | |
| Partner during the last sexual encounter | <0.001 | |||||
| Stable male sexual partner | 187 (23.4) | 66 (45.2) | 253 (26.8) | 1.00 | ||
| Occasional male sexual partner | 612 (76.6) | 80 (54.8) | 692 (73.2) | 0.37 (0.26 to 0.53) | <0.001 | |
| Prevention tools used during the last anal intercourse | <0.001 | |||||
| None | 56 (7.0) | 49 (33.8) | 105 (11.1) | 16.72 (9.79 to 28.55) | <0.001 | |
| Exclusively a condom | 34 (4.3) | 21 (14.5) | 55 (5.9) | 11.80 (6.10 to 22.82) | <0.001 | |
| At least PrEP | 554 (69.4) | 29 (20.0) | 583 (61.8) | 1.00 | ||
| Not concerned (no anal intercourse) | 154 (19.3) | 46 (31.7) | 200 (21.2) | 5.71 (3.47 to 9.39) | <0.001 | |
Created by the authors.
Bold values denote statistical significance at the p < 0.05 level.
ERAS, Enquête Rapport au Sexe; PrEP, pre-exposure prophylaxis.