Results of investigations in relation to clinical presentation, attendance and vaccination
| Timeline | |||||
| T0 | T1* | T11† | T16‡ | T20§ | |
| First attendance | Vaccine dose 1 | Vaccine dose 2 | Second attendance | Third attendance | |
| Symptoms and signs | Rectal pain, rectal discharge and inguinal lymphadenopathy | Headache, back pain, neck pain, anal sore and apthous mouth ulcer | Rectal pain, rectal discharge | ||
| Investigations (sites) | |||||
| CT/GC NAAT (Aptima Combo, Hologic) (rectal and pharyngeal swabs, urine) | Negative | Negative | GC positive (rectal) | ||
| HSV PCR (in-house lab based test at UKHSA, Bristol) (rectal, etc) | HSV-2 positive (rectal) | Negative (anal sore) Negative (mouth ulcer) | Not tested | ||
| T.pallidum PCR (in-house lab based test at UKHSA, Colindale) (rectal etc)) | Negative (rectal) | Negative (anal sore) Negative (ulcer in mouth) | Negative (rectal) | ||
| Orthopoxvirus DNA PCR and mpox virus PCR (UKHSA lab developed test) (rectal, etc) | Positive (rectal) | Positive (anal sore) Negative (ulcer in mouth) | Negative (rectal) | ||
| HIV (Architect HIV Ag/Ab combo assay (Abbott)) (serum) | Negative | Negative | Negative | ||
| Hepatitis C (Architect anti-HCV assay (Abbott)) (serum) | Negative | Negative | Negative | ||
| RPR (rapid plasma reagin) (serum) | 1:2 | Positive neat | Positive neat | ||
*1 week after first attendance.
†11 weeks after first attendance.
‡16 weeks after first attendance.
§4 weeks after second attendance.
CT, Chlamydia trachomatis; GC, Neisseria gonorrhoeae; HSV, herpes simplex virus; mpox, monkeypox.