Table 1

Minimal inhibitory concentration (MIC) of PPCM against the Neisseria gonorrhoeae strains used in this study as determined by agar dilution and microtitre plate assays

Strain	Susceptibility profile	MIC (µg/mL)
Strain	Susceptibility profile	Agar dilution	Microtitre plate
FA1090*	STM^R	25	100
MS11*	STM^R	100	200
H041 (WHO X)†	PEN-G^R, TET^R, AXI^I, CIP^HLR, CFX^HLR, CRO^HLR	25	100
F89†	Pen-G^R, TET^R, CFX^HLR, CRO^HLR, CIP^HLR	≤5	50
WHO F†	susceptible	≤5	50
WHO G†	PEN-G^I, TET^R, CIP^LLR	≤5	50
WHO K†	PEN-G^R, TET^R, CIP^HLR, CFX^LLR	100	100
WHO L†	PEN-G^R, TET^R, CIP^HLR, CRO^LLR	100	200
CONUS-9542‡	TET^R, CIP^R	100	Not determined
CONUS-3668‡	PEN^R, CIP^R	≤5	Not determined
CONUS-6364‡	PEN^R, CIP^R	25	Not determined

*Commonly used laboratory N. gonorrhoeae strains.14
†Multidrug-resistant, ceftriaxone-resistant N. gonorrhoeae strains.27 28
‡US isolates; from the USU GC Resistance Repository and Reference Laboratory isolated in 2017 (CONUS-9542), 2019 (CONUS-3668) and 2014 (CONUS-6364).
AZI, azithromycin; CFX, cefixime; CIP, ciprofloxacin; CRO, ceftriaxone; HLR, high-level resistant; I, intermediate susceptible; LLR, low-level resistant; N/A, not available; PEN G, penicillin G; PPCM, polyphenylene carboxymethylene; R, resistant; STM, streptomycin; TET, tetracycline.