Univariable determinants of past/current prevalent HCV infection at baseline among individuals enrolled in the Dutch national PrEP programme between July 2019 and December 2022
| Total (n=10 563) | |||
| OR* | 95% CI | P value | |
| Age per 10 years, continuous | 1.57 | 1.31 to 1.88 | <0.01 |
| Key population | |||
| MSM | Ref | 0.24 | |
| Transgender | 2.03 | 0.63 to 6.49 | |
| Region of origin | |||
| Dutch | Ref | 0.34 | |
| Non-Dutch | 1.28 | 0.78 to 2.11 | |
| Educational level | |||
| At least college degree | Ref | 0.41 | |
| Less than college degree | 0.80 | 0.46 to 1.38 | |
| Use of PrEP before enrolment | 3.03 | 1.79 to 5.13 | <0.01 |
| Choice of PrEP regimen | |||
| Daily | Ref | 0.62 | |
| Event driven | 1.12 | 0.68 to 1.86 | |
| Missing | 1.18 | 0.42 to 3.36 | |
| Number of sex partners per ln(n+1) increase6M | 1.10 | 0.92 to 1.33 | 0.29 |
| Receptive CAS6M | 2.73 | 1.25 to 5.98 | 0.01 |
| Reporting chemsex†6M | 2.44 | 1.49 to 3.99 | <0.01 |
| Reporting sex work6M | 0.67 | 0.16 to 2.76 | 0.58 |
| STI diagnosis‡ | 1.94 | 0.96 to 3.94 | 0.07 |
| IDU6M | 6.61 | 2.35 to 18.61 | <0.01 |
*Indicates the relative increase or decrease in odds for each socioeconomic characteristic or sexual behaviour when present at NPP consultation visit.
†Defined as the use of methamphetamine, GHB/GBL and/or mephedrone before or during sex.
‡Diagnosed with an anal chlamydia/gonorrhoea or a syphilis infection at visit.
CAS, condomless anal sex; CI, confidence interval; GBL, γ-butyroactone; GHB, γ-hydroxybutyric acid; HCV, hepatitis C virus; IDU, injecting drug use; ln, natural log; 6M, during the previous 6 months; MSM, men who have sex with men; NPP, national PrEP programme; OR, odds ratio; PrEP, pre-exposure prophylaxis; Ref, reference category; STI, sexually transmitted infection.