Summary
To test the hypothesis that households of anti-HCV positive subjects might be at increased risk of HCV infection, a case-control study was carried out comparing 518 family members of 205 anti-HCV positive subjects (index carriers) with 281 family members of 100 anti-HCV negative subjects (index controls), consecutively observed in ten gastroenterology units in different Italian regions. The index carriers were age and sex matched to the index controls and their households were similar with respect to the main sociodemographic characteristics. Anti-HCV antibodies were found in 6.9% (36/518) of household members of index carriers and in 3.2% (9/281) of household members of index controls (p<0.05). The results of multiple logistic regression analysis showed that being over 50 years of age was the sole independent predictor for a household contact of the likelihood of being anti-HCV positive (O.R. 3.6; C.I. 95%=1.5−8.2). Being in the household of an anti-HCV index carrier was marginally associated to anti-HCV positivity (O.R. 2.0; C.I. 95%=0.9−4.6). No association was found for sex, area of residence, family size, lowest level of schooling, or any type of family relationship. These findings are not in compliance with the statement that household contacts of HCV carriers are at increased risk of HCV infection. The 3.2% anti-HCV prevalence rate observed among household contacts of anti-HCV negative index controls may suggest that the true anti-HCV prevalence in the general population in Italy is nearly 2.5 times as high as the 1.3% found in Italian blood donors.
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References
Alter, M. J. The detection, transmission and outcome of hepatitis C virus. Infect. Ag. Dis. 2 (1993) 155–166.
Alter, M. J., Hadler, S. C., Judson, F. N. Risk factors for acute non-A, non-B hepatitis in the United States and association with hepatitis C virus infection. JAMA 264 (1990) 2231–2235.
Bernier, R. H., Sampliner, R., Gerety, R., Tabor, E., Hamilton, F., Nathanson, N. Hepatitis B infection in households of chronic carriers of hepatitis B surface antigen. Am. J. Epidemiol. 116 (1982) 199–211.
Everhart, J. E., Di Bisceglie, A. M., Murray, L. M., Alter, H. J., Malpoder, J. J., Kuo, G., Hoofnagle, U. J. Risk for non-A, non-B (type C) hepatitis through sexual or household contact with chronic carriers. Ann. Intern. Med. 112 (1990) 544–545.
Peano, G. M., Fenoglio, L. M., Menardi, G., Bollo, R., Marenchino, D., Fenoglio, S. Heterosexual transmission of hepatitis C virus in family groups without risk factors. BMJ 305 (1992) 1473–1474.
Kao, J. H., Chen, P. J., Yang, P. M., Lai, M. Y., Sheu, J. C., Wang, T. H., Chen, D. S. Intrafamilial transmission of hepatitis C virus: the important role of infections between spouses. J. Infect. Dis. 166 (1992) 900–903.
Oshita, M., Hayashi, N., Fashara, A., Yuki, N., Takehara, T. Prevalence of hepatitis C virus in family members of patients with hepatitis C. J. Med. Virol. 41 (1993) 251–255.
Bresters, D., Mauser-Bunschoten, E. P., Reesink, H. W., Roosendaal, G., Van Der Poel, C. L. Sexual transmission of hepatitis C. Lancet 342 (1993) 210–211.
Brettler, D. B., Manucci, P. M., Gringeri, A. The low risk of hepatitis C virus transmission among sexual partners of hepatitis C infected hemophiliac males. Blood 80 (1992) 540–543.
Osmond, D. H., Padian, N. S., Sheppard, H. W., Glass, S., Shiboski, S. C., Reingold, A. Risk factors for hepatitis C virus seropositivity in heterosexual couples. JAMA 269 (1993) 361–365.
Akahane, Y., Kojima, M., Sugai, Y., Sakomoto, M., Miyazaki, Y., Tanaka, T. Hepatitis C virus infection in spouses of patients with type C chronic liver disease. Ann. Intern. Med. 120 (1994) 748–752.
Chang, T. T., Liou, T. C., Young, K. C., Lin, X. Z. Intrafamilial transmission of hepatitis C virus: the important role of inapparent transmission. J. Med. Virol. 42 (1994) 91–96.
Thomas, D. L., Zenilamn, J. M., Alter, H. J., Shih, J. W., Galai, N., Carella, A. V., Quinn, T. C. Sexual transmission of hepatitis C virus among patients attending sexually transmitted diseases clinics in Baltimore. An analysis of 309 sex partnerships. J. Infect. Dis. 171 (1995) 768–775.
Klinbaum, D. G., Kupper, L. L., Chambless, L. E. Logistic regression analysis of epidemiological data. Theory and practice. Commun. Statist. Theory Methods 11 (1982) 485–547.
Kahn, H. A., Sempos, C. T. Statistical methods in epidemiology. Oxford University Press, New York 1989, pp. 56–58.
Sagnelli, E., Stroffolini, T., Ascione, A., Bonino, F., Chiaramonte, M., Colombo, M. The epidemiology of hepatitis delta infection in Italy. J. Hepatology 15 (1992) 211–215.
Chiaramonte, M., Stroffolini, T., Caporaso, N., Coppola, R., Craxì, A., Gaeta, G. B., Sagnelli, E., Zanetti, A. R. Hepatitis C virus infection in Italy: a multicentric seroepidemiological study. Ital. J. Gastroenterol. 23 (1991) 555–558.
Romanò, L., Azara, A., Chiaramonte, M., De Mattia, D., Giammanco, A., Moschen, M. E., Scarpa, B., Stroffolini, T., Zanetti, A. R. Low prevalence of anti-HCV antibodies among Italian children. Infection 22 (1994) 350–352.
D'Amelio, R., Stroffolini, T., Matricardi, P. M., Nisini, R. Low prevalence of anti-HCV antibodies among Italian air force recruits. Scand. J. Infect. Dis. 27 (1995) 12–14.
Bellentani, S., Tiribelli, C., Saccoccio, G., Sodde, M., Fratti, N., De Martin, C. Prevalence of chronic liver disease in the general population of Northern Italy: the Dyonysius study. Hepatology 20 (1994) 1442–1449.
Stroffolini, T., Menchinelli, M., Taliani, G., Dambruoso, V., Poliandri, G. High prevalence of hepatitis C virus infection in a small central Italian town: lack of evidence of parenteral exposure. Ital. J. Gastroenterol. 27 (1995) 235–238.
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Additional collaborators:G. Pilleri, M. D.,M. Bernasconi, M. D. (Cagliari);O. G. Manghisi, M. D.,R. Cuppone, M. D. (Castellana Grotte);M. A. Freni, M. D.,A. Aiello, M. D.,A. Spadaro, M. D. (Messina);G. Raimondo, M. D.,G. Longo, M. D. (Messina);A. Picciotto, M. D.,E. Bordellini, M. D. (Genoa);M. Toti, M. D.,C. Nencioni, M. D. (Grosseto);M. Chiaramonte, M. D.,U. Lorenzoni, M. D. (Padua);A. Craxi, M. D.,L. M. Valenza, M. D. (Palermo);A. Andriulli, M. D.,F. Spirito, M. D.,A. Mangia, M. D. (S. Giovanni Rotondo);F. Bonino, M. D.,M. Baldi, M. D.,M. Capalbo, M. D. (Turin).
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Sagnelli, E., Gaeta, G.B., Felaco, F.M. et al. Hepatitis C virus infection in households of anti-HCV chronic carriers in Italy: A multicentre case-control study. Infection 25, 346–349 (1997). https://doi.org/10.1007/BF01740815
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DOI: https://doi.org/10.1007/BF01740815