Abstract
Zidovudine (ZDV) treatment during pregnancy, delivery and the postnatal period is effective in reducing the maternal-infant transmission of the human immunodeficiency virus. Reported adverse effects in the neonate during this long-term treatment are bone marrow suppression and elevation in aspartate aminotransferase activity. We report a case of severe ZDV-associated lactic acidosis in a neonate, which resolved rapidly following discontinuation of ZDV. The mechanisms leading to this side effect are poorly understood.
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References
Connor EM, Sperling RS, Gelber R, Kiselev P, Scott G, O’Sullivan MJ, VanDyke R, Bey M, Shearer W, Jacobson RL et al (1994) Reduction of maternal-infant transmission of human immunodeficiency virus type 1 with zidovudine treatment. N Engl J Med 331: 1173–1180
Pädiatrische AIDS-Gruppe Schweiz (PAGS), Kommission der Schweizerischen Gesellschaft für Pädiatrie, Subkommission Klinik (SKK) der Eidgenössischen Kommission für AIDS-Fragen (EKAF), Arbeitsgruppe HIV der Schweizerischen Gesellschaft für Gynäkologie und Geburtshilfe (1994) Zidovudine zur Prophylaxe der HIV Übertragung von der infizierten Mutter auf ihr Kind. Schweiz Ärztezeitung 75: 1508–1509
Tolsa JF, Cutting J, Sekarski N, Payot M, Micheli JL, Calame A (1995) Magnesium sulphate as an alternative and safe treatment for severe persistent pulmonary hypertension of the newborn. Arch Dis Child Fetal Neonatal Ed 72: F184–187
Monpoux F, Dageville C, Bongain A, Sirvent N, Maillotte AM, Mariani R, Gillet JY (1997) Tolérance biologique de l’azidothymidine administrée en période périnatale chez le nouveau-né de mère VIH-1 séropositive. Ann Pediatr 44: 87–93
Chattha G, Arieff AI, Cummings C, Tierney LM Jr (1993) Lactic acidosis complicating the acquired immunodeficiency syndrome. Ann Intern Med 118: 37–39
Masio C, Jacomet C, Jupas JJ, Lebrette MG, Rozenbaum W (1994) Acidose lactique chez des patients infectés par le VIH. La Presse Médicale 23: 717
Boucher FD, Modlin JF, Weiler S, Ruff A, Mirochnick M, Pelton S, Wilfert C, McKinney R Jr, Crain MJ, Elkins MM et al (1993) Phase I evaluation of zidovudine administered to infants exposed at birth to the human immunodeficiency virus. J Pediatr 122:137–144
Chatton JY, Munafo A, Chave JP, Steinhauslin F, Roch-Ramel F, Glauser MP, Biollaz J (1992) Trimethoprim, alone or in combination with sulphamethoxazole, decreases the renal excretion of zidovudine and its glucuronide. Br J Clin Pharmacol 34: 551–554
Chen CH, Vazquez-Padua M, Cheng YC (1991) Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity. Mol Pharmacol 39: 625–628
Gopinath R, Hutcheon M, Cheema-Dhadli S, Halperin M (1992) Chronic lactic acidosis in a patient with acquired immunodeficiency syndrome and mitochondrial myopathy: biochemical studies. J Am Soc Nephrol 3:1212–1219
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Scalfaro, P., Chesaux, J.J., Buchwalder, P.A. et al. Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment. Intensive Care Med 24, 247–250 (1998). https://doi.org/10.1007/s001340050558
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DOI: https://doi.org/10.1007/s001340050558