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Central pontine myelinolysis in AIDS

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Abstract

Central pontine myelinolysis (CPM) is an uncommon complication in sick patients with severe underlying disorders such as chronic alcoholism, malignancy, malnutrition and hyponatraemia. We report two patients with advanced HIV infection who developed CPM. In one case the diagnosis was not suspected in life, in the other the diagnosis was made just before death, on the basis of magnetic resonance (MR) imaging appearances. At post mortem there was a close correlation between the MR abnormalities and the anatomic changes in the pons.

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Authors and Affiliations

  1. Division of Pathology and Infectious Diseases, University College London Medical School, Mortimer Market Centre, London WC1E 6AU, UK e-mail: rmiller@gum.ucl.ac.uk, Tel.: +44-171-380-9945, Fax: +44-171-380-9669, , , , , , GB

    R. F. Miller

  2. Department of Neurology, University College London Medical School, London W1P 6DB, UK, , , , , , GB

    Michael J. G. Harrison

  3. Department of Imaging, University College London Hospitals, London W1N 8AA, UK, , , , , , GB

    Margaret A. Hall-Craggs

  4. Department of Neuropathology, Institute of Neurology, London WC1N 3BG, UK, , , , , , GB

    Francesco Scaravilli

Authors
  1. R. F. Miller
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  2. Michael J. G. Harrison
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  3. Margaret A. Hall-Craggs
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  4. Francesco Scaravilli
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Additional information

Received: 6 March 1998 / Revised, accepted: 11 May 1998

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Miller, R., Harrison, M., Hall-Craggs, M. et al. Central pontine myelinolysis in AIDS. Acta Neuropathol 96, 537–540 (1998). https://doi.org/10.1007/s004010050931

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  • DOI: https://doi.org/10.1007/s004010050931

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