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Phenotypic and genotypic characterization of prolyliminopeptidase-negative Neisseria gonorrhoeae isolates in Denmark

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An Erratum to this article was published on 21 June 2005

Abstract

In the study presented here 26 recent Danish clinical isolates of prolyliminopeptidase (PIP)-negative Neisseria gonorrhoeae were phenotypically and genotypically characterized to investigate whether one or more PIP-negative strains are circulating in the Danish community. The profiles of these isolates were compared with those of three isolates from a recent outbreak of PIP-negative N. gonorrhoeae infection in the UK. Twenty-five of the Danish isolates and all three UK isolates had similar antibiograms and were designated serovar IB-4. Genotypic characterization by pulsed-field gel electrophoresis, porB1b gene sequencing, and opa-typing revealed that these isolates were indistinguishable or closely related. The results indicate that at least one PIP-negative N. gonorrhoeae strain is currently circulating in the Danish community, and this strain is indistinguishable from the one that caused an outbreak in the UK.

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Authors and Affiliations

  1. Department of Clinical Microbiology, H:S Hvidovre Hospital, Kettegaard allé 30, 2650, Hvidovre, Denmark

    H. Fjeldsøe-Nielsen & A. Friis-Møller

  2. Swedish Neisseria gonorrhoeae Reference Laboratory, Department of Clinical Microbiology, Örebro University Hospital, 70185, Örebro, Sweden

    M. Unemo & H. Fredlund

  3. Danish Neisseria gonorrhoeae Reference Laboratory, Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Artillerivej 5, 2300, Copenhagen S, Denmark

    S. V. Hjorth & L. M. Berthelsen

  4. Scottish Neisseria gonorrhoeae Reference Laboratory, Department of Clinical Microbiology, Royal Infirmary of Edinburgh, Little France, Edinburgh, EH16 4SA, Scotland, UK

    H. M. Palmer

Authors
  1. H. Fjeldsøe-Nielsen
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  2. M. Unemo
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  3. H. Fredlund
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  4. S. V. Hjorth
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  5. L. M. Berthelsen
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  6. H. M. Palmer
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  7. A. Friis-Møller
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Correspondence to A. Friis-Møller.

Additional information

An erratum to this article can be found at http://dx.doi.org/10.1007/s10096-005-1352-4

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Fjeldsøe-Nielsen, H., Unemo, M., Fredlund, H. et al. Phenotypic and genotypic characterization of prolyliminopeptidase-negative Neisseria gonorrhoeae isolates in Denmark. Eur J Clin Microbiol Infect Dis 24, 280–283 (2005). https://doi.org/10.1007/s10096-005-1319-5

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  • DOI: https://doi.org/10.1007/s10096-005-1319-5

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