Role of bacterial vaginosis–associated microorganisms in endometritis☆,☆☆,★,★★
Section snippets
Study population
Women with clinically suspected pelvic inflammatory disease were enrolled into this study of the etiology, pathogenesis, and therapy of pelvic inflammatory disease at Harborview Medical Center from 1984 to 1988. All women had a history of lower abdominal pain and had tenderness on bimanual pelvic examination of the uterus and adnexa. Patients were excluded if they received more than a single dose of an antimicrobial agent in the 14 days before presentation, had pelvic or abdominal surgery in
RESULTS
Histologic endometritis was detected in 117 (65%) of the 178 women with suspected pelvic inflammatory disease. Characteristics of the women with or without histologic evidence of endometritis are summarized in Table I. Women with endometritis were more likely to be nonwhite, to have had a new sexual partner in the past month, and to perceive themselves as probably or definitely infertile. Women with endometritis were significantly more likely to be in the first half of the menstrual cycle than
COMMENT
In this study of 178 women with clinically suspected pelvic inflammatory disease, the recovery of anaerobic gram-negative rods from the endometrium was associated with histologic endometritis. However, the clinical entity of bacterial vaginosis was not independently associated with endometritis in the multivariate analysis, suggesting that invasion of the upper female genital tract by bacterial vaginosis - associated microorganisms is a greater risk for histologic endometritis than bacterial
Acknowledgements
We thank Cathy M. Critchlow, PhD, for biostatistical support.
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Identification and Treatment of Acute Pelvic Inflammatory Disease and Associated Sequelae
2022, Obstetrics and Gynecology Clinics of North AmericaBacterial vaginosis and its association with infertility, endometritis, and pelvic inflammatory disease
2021, American Journal of Obstetrics and GynecologyCitation Excerpt :Greater than 85% of PID cases are caused by BV-related bacteria and/or STIs.4,14 Of those cases, fewer than half are caused by Neisseria gonorrhoeae or Chlamydia trachomatis, suggesting an important role for ascension of BV-associated anaerobic bacteria and other non-BV–related pathogens (eg, Mycoplasma genitalium) in endometritis and PID pathophysiology.15–17 PID and endometritis are associated with adverse health outcomes, such as chronic pain, ectopic pregnancy, tubo-ovarian abscess, and infertility.18,19
Treatment of uncomplicated pelvic inflammatory disease: CNGOF and SPILF Pelvic Inflammatory Diseases Guidelines
2019, Gynecologie Obstetrique Fertilite et SenologiePelvic inflammatory diseases: Microbiologic diagnosis – CNGOF and SPILF Pelvic Inflammatory Diseases Guidelines
2019, Gynecologie Obstetrique Fertilite et SenologieChapter 16 - Evaluation of the Cyclic Endometrium and Benign Endometrial Disorders
2017, Diagnostic Gynecologic and Obstetric Pathology
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From the Departments of Obstetrics and Gynecology,a Pathology,b and Medicinec and the Center for Acquired Immunodeficiency Syndrome and Sexually Transmitted Diseases,d University of Washington.
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Supported by National Institutes of Heath grant AI12192.
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Reprint requests: Sharon L. Hillier, PhD, University of Pittsburgh/Magee-Womens Hospital, Department of Obstetrics, Gynecology, and Reproductive Sciences, 300 Halket St., Pittsburgh, PA 15213-3180.
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