Research LettersWhole-body positron emission tomography in patients with HIV-1 infection
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2020, PET ClinicsCitation Excerpt :Nonetheless, the potential to supplement the initial whole-body FDG-PET/computed tomography (CT) scan with focused PET/MR imaging of suspicious findings is not far-fetched in our time with novel fast reconstruction algorithms that allows for almost instantaneous image interpretation. The same is probably true for other whole-body disorders, where the FDG-PET/CT scan is finding its place, but where the literature is still lacking, for example, in human immunodeficiency virus infection, where studies have demonstrated correlation between FDG uptake pattern in lymph nodes, disease stage, and viral load.8,9 A specific challenge is the effect of treatment on FDG-uptake, which not only is exploited in monitoring treatment response, but also may cause false-negative findings if patient preparation is not controlled sufficiently, especially in vasculitides.
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2015, BloodCitation Excerpt :Clinical evaluation includes a history and physical, complete blood count with differential, albumin level, liver and kidney function, baseline pulmonary function test for patients undergoing bleomycin-containing regimens, and 18FDG-PET with integrated or concurrent CT of the neck, chest, abdomen, and pelvis.50 18FDG-PET must be interpreted with caution because HIV viremia and certain OIs can cause 18FDG-avid nodes.51-53 Although not validated in the setting of HIV-cHL, 18FDG-PET is both sensitive and specific for detecting bone marrow involvement in cHL.
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2014, Medecine et Maladies InfectieusesFDG-PET imaging in HIV infection and tuberculosis
2013, Seminars in Nuclear MedicineCitation Excerpt :Increased tissue FDG uptake preceded fulminant virus replication at these sites, suggesting that a diffusible factor of host or viral origin was responsible for lymphoid tissue changes. In humans, Scharko et al31 performed FDG-PET imaging in 15 patients suffering from HIV-1. They observed distinct lymphoid tissue activation in the head and neck during acute disease, a generalized pattern of peripheral LN activation at midstages, and involvement of abdominal LNs during late disease, suggesting that lymphoid tissues are engaged in a predictable sequence.