Original InvestigationRenal pathology and HIV infection in Thailand★
Section snippets
Patients
Between 1995 and 1996, HIV-infected patients receiving medical treatments in Chulalongkorn University Hospital (Bangkok, Thailand) were screened for abnormal proteinuria. Those patients with total proteinuria greater than 1.5 g/d of protein were considered for enrollment. Exclusion criteria included positive antinuclear antibody, positive hepatitis B virus surface antigen, positive anti–hepatitis C virus antibody, and fasting plasma glucose levels greater than 140 mg/dL. Patients with
Clinical features
The data listed in Table 1 come from 14 men and 12 women, ranging in age from 17 to 52 years (mean age, 31 years).
Patient No. Age (yr)/ Sex Risk Factor Stage of HIV Disease CD4 Count Serum Cr (mg/dL) 24-Hour Urine Protein (g/d) Opportunistic Infection Pathological Diagnosis 1 27/M Heterosexual Early symptomatic 132 0.9 3.1 Pleural tuberculosis Mesangial proliferative GN 2 26/W Heterosexual Late symptomatic 70 1.2 1.5 Cryptococcal meningitis Mesangial proliferative GN 3
Discussion
The relationship between HIV infection and renal disease has been established by several investigators over the course of a decade.3, 4, 5 Glomerulopathy in HIV-infected patients has been widely reported by various centers, mostly in North America and Western Europe.6, 7 More than 350 patients with histologically proven HIVAN with unique features, more than 75 patients with diffuse mesangial proliferative glomerulonephritis, and 100 patients with other glomerulopathies have been reported in the
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Cited by (57)
Absence of HIV-Associated Nephropathy Among Antiretroviral Naive Adults With Persistent Albuminuria in Western Kenya
2017, Kidney International ReportsCKD and Infectious Diseases in Asia Pacific: Challenges and Opportunities
2016, American Journal of Kidney DiseasesCitation Excerpt :However, in contrast to the black population from sub-Saharan Africa, Asians infected with HIV seem to be at a lower risk for developing HIV-associated nephropathy. In most series of patients with HIV infection and kidney disease from the region, kidney disease seems to have been etiologically unrelated to the HIV infection.51-53 At the same time, these patients remain at increased risk for kidney disease as a result of predilection to other infections or drug nephrotoxicity.53
Recurrent HIV-associated immune complex glomerulonephritis with lupus-like features after kidney transplantation
2013, American Journal of Kidney DiseasesAcute interstitial nephritis with predominant plasmacytic infiltration in patients with HIV-1 infection
2012, American Journal of Kidney DiseasesIgnoring the Obvious Missing Piece of Chronic Kidney Disease in HIV: Cigarette Smoking
2010, Journal of the Association of Nurses in AIDS CareCKD in HIV-Infected Patients Other Than HIV-Associated Nephropathy
2010, Advances in Chronic Kidney DiseaseCitation Excerpt :FSGS was found only among black patients.84 There were no cases of HIVAN in a study from Thailand of 26 Asian HIV-infected patients who had a kidney biopsy.85 Twenty-three patients had ICGN, including 17 with mesangial proliferative glomerulonephritis, 2 each with IgA nephropathy or diffuse proliferative glomerulonephritis and 1 each with MPGN or membranous nephropathy.
Received September 9, 1997; accepted in revised form August 8, 1998.
Supported by a grant from the Chongkolnee Foundation, Bangkok, Thailand.
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Address reprint requests to Kearkiat Praditpornsilpa, MD, Department of Medicine, Renal Unit, Police General Hospital, Bangkok, 10500, Thailand. E-mail: [email protected]