ResearchBasic science: ObstetricsAmong pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associated with interleukin-1β
Section snippets
Study design
All women enrolling for prenatal care at 3 hospital-based clinics and 1 community-based clinic located in Philadelphia between January 2002-September 2004 were screened for eligibility. Eligible women were enrolled after completing an informed consent as per the institutional ethics committees guidelines. Women were considered eligible for participation if they: (1) were at less than 20 weeks’ gestation at the time of enrollment; (2) spoke either English or Spanish; (3) had a singleton
Results
A total of 1961 eligible women came for their antenatal visit between January 2002-September 2004. Of these women, 1804 (92%) subsequently consented to participate. BV diagnosis was not obtained for 19 of enrolled women (1.1%). A full 44% (n = 802) of study participants were diagnosed with BV (Nugent score 7-10). Among this group, we analyzed host microbial and immune parameters and abstracted medical records for a random subset of 265 women. For this analysis, to minimize potential confounding
Comment
Evidence is accumulating in support of an interrelationship between the host and the microbiological milieu in BV.2, 8, 9, 13, 22, 33 Very recent research highlights a vast heterogeneity in response to microbes among women with BV, which cannot be appreciated by common clinical criteria used to diagnose this condition. Although many aspects of BV remain enigmatic,1, 4, 9, 11 an understanding of the mechanisms that regulate the homeostasis of vaginal microbial flora and local immunity could lead
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2021, Medicine in MicroecologyCitation Excerpt :Not only that, Gardnerella can produce sialic acidase and proline aminopeptidase, which can degrade protective factors such as mucin in the vagina, make thinner vaginal secretions, and promote the adhesion of anaerobic bacteria on the surface of the vaginal mucosa. Moreover, Gardnerella can use amino acids to produce large amounts of amines, causing an increase in vaginal pH, which facilitates the growth of pathogenic bacteria and extremely increases the risk of preterm birth [32]. In addition, BV-induced preterm birth may be related to local immune response.
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Cite this article as: Cauci S, Flatow Culhane J, Di Santolo M, et al. Among pregnant women with bacterial vaginosis, the hydrolytic enzymes sialidase and prolidase are positively associated with interleukin-1β. Am J Obstet Gynecol 2008;198:132.e1-132.e7.
Supported in part by the Centers for Disease Control and Prevention/Association of Teachers of Preventive Medicine TS-0626 and TS-0561. The authors do not have a commercial or other association that might pose a conflict of interest.