Abstract
Acute hepatitis with lactic acidosis is a life-threatening but reversible toxic effect on mitochondria of HIV-1 nucleoside-analogue treatment. We report fatal portal hypertension, liver failure, and persistent mitochondrial dysfunction in a man aged 65 years with HIV-1 infection who had recovered from nucleoside-analogue-induced acute hepatitis and lactic acidaemia more than 18 months previously. We believe that symptom free patients who receive nucleoside-analogue therapy should have hepatic function constantly monitored, especially those with past or present lactic acidaemia.
MeSH terms
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Acute Disease
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Aged
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Anti-HIV Agents / adverse effects*
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Anti-HIV Agents / therapeutic use
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Chemical and Drug Induced Liver Injury / complications
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Chemical and Drug Induced Liver Injury / pathology*
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Didanosine / adverse effects
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Didanosine / therapeutic use
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Fatal Outcome
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Fatty Liver / pathology
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HIV Infections / drug therapy*
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HIV-1*
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Humans
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Hypertension, Portal / chemically induced*
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Hypertension, Portal / complications
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Male
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Mitochondria, Liver / drug effects*
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Stavudine / adverse effects
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Stavudine / therapeutic use
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Zidovudine / adverse effects
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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Zidovudine
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Stavudine
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Didanosine