Since the implementation of highly active antiretroviral therapy (HAART) in the United States in 1996, the number of persons diagnosed with acquired immunodeficiency syndrome (AIDS) and the number of deaths among persons with AIDS have declined substantially; as a result, the number of persons living with AIDS has increased. This report describes changes in AIDS incidence, prevalence, and deaths among persons with AIDS during January 1996-December 2000. Surveillance data indicate a slowing of declines in new AIDS diagnoses, continued declines in deaths among persons with AIDS, and increases in the number of persons living with AIDS. These findings indicate that AIDS continues to place a burden on the health-care system in the United States and that access to medical and preventive services must be improved to reduce the public health impact of AIDS.