Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults

Veronica Rainone; Vania Giacomet; Francesca Penagini; Valentina Fabiano; Francesca Calascibetta; Chiara Mameli; Stefania Pisanelli; Gian Vincenzo Zuccotti; Mario Clerici; Daria Trabattoni

doi:10.1097/QAD.0000000000000597

Human papilloma virus vaccination induces strong human papilloma virus specific cell-mediated immune responses in HIV-infected adolescents and young adults

AIDS. 2015 Mar 27;29(6):739-43. doi: 10.1097/QAD.0000000000000597.

Authors

Veronica Rainone¹, Vania Giacomet, Francesca Penagini, Valentina Fabiano, Francesca Calascibetta, Chiara Mameli, Stefania Pisanelli, Gian Vincenzo Zuccotti, Mario Clerici, Daria Trabattoni

Affiliation

¹ aDepartment of Biomedical and Clinical Sciences 'L. Sacco', University of Milan bDepartment of Pediatrics, University of Milan, L. Sacco Hospital cDepartment of Pediatrics, University of Milan, Ospedale dei Bambini V. Buzzi dDepartment of Physiopathology Medical-Surgery and Transplantation, University of Milan eDon C. Gnocchi Foundation ONLUS, IRCCS, Milan, Italy.

PMID: 25849837
DOI: 10.1097/QAD.0000000000000597

Abstract

The ability of a quadrivalent human papilloma virus (HPV)-16/18/6/11 virus-like particles vaccine (Gardasil) to elicit HPV-specific cell-mediated immune responses was evaluated in antiretroviral therapy (ART)-treated HIV-infected young adults. Results showed that, after three doses of vaccine, central memory and effector memory CD4(+) and CD8(+) T lymphocytes, as well as HPV-specific interleukin (IL)2(+)/CD4(+), interferon-gamma (IFN-γ(+))/CD4(+), IFN-γ(+)/CD8(+) and tumour necrosis factor-alpha (TNF-α)(+)/CD8(+) T lymphocytes and Perforin and Granzyme B secreting CD8(+) T lymphocytes were significantly increased. Notably, results obtained in HIV-infected patients were comparable to those seen in HIV-uninfected age-matched healthy controls.

Publication types

Clinical Study
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Cytokines / metabolism
HIV Infections / complications
HIV Infections / immunology*
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 / administration & dosage*
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18 / immunology*
Human papillomavirus 16
Humans
Immunity, Cellular / drug effects*
Longitudinal Studies
Papillomavirus Infections / immunology
Papillomavirus Infections / prevention & control*
Prospective Studies
T-Lymphocyte Subsets / immunology*
Vaccination / methods*
Young Adult

Substances

Cytokines
Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18