Abstract
Sixty-two women were randomized in a double-blind fashion to receive one of two antibiotic regimens for the treatment of clinically diagnosed pelvic inflammatory disease. Thirty of 31 patients (96.8%) receiving a combination of cefoxitin with doxycycline and 28 of 31 (90.3%) receiving a combination of clindamycin with amikacin responded to therapy (P = not significant). Chlamydia trachomatis, Neisseria gonorrhoeae, or both were isolated from 13.3, 7.0, and 4.8% of patients, respectively. Of the four patients not responding to therapy, all had inflammatory complexes. Cefoxitin/doxycycline and clindamycin/amikacin are both effective in the treatment of pelvic inflammatory disease.
Publication types
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Clinical Trial
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Comparative Study
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Randomized Controlled Trial
MeSH terms
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Acute Disease
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Amikacin / administration & dosage
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Anti-Bacterial Agents / therapeutic use*
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Cefoxitin / administration & dosage
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Cervix Uteri / microbiology
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Chlamydia trachomatis / isolation & purification
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Clindamycin / administration & dosage
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Clinical Trials as Topic
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Double-Blind Method
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Doxycycline / administration & dosage
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Drug Therapy, Combination
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Female
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Humans
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Neisseria gonorrhoeae / isolation & purification
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Pelvic Inflammatory Disease / diagnosis
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Pelvic Inflammatory Disease / drug therapy*
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Pelvic Inflammatory Disease / microbiology
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Prospective Studies
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Random Allocation
Substances
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Anti-Bacterial Agents
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Clindamycin
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Cefoxitin
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Amikacin
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Doxycycline