Abstract
Long-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest in many tissues, a common disease mechanism can explain the diverse clinical events. A better understanding of these disorders will shed light on genetic mitochondrial diseases and lead to the design of safer and more effective antiviral drugs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Acquired Immunodeficiency Syndrome / drug therapy
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Animals
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Antiviral Agents / adverse effects
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Antiviral Agents / chemistry
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Antiviral Agents / toxicity*
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Arabinofuranosyluracil / analogs & derivatives
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Arabinofuranosyluracil / toxicity
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DNA, Mitochondrial / drug effects
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DNA-Directed DNA Polymerase / drug effects
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Didanosine / toxicity
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Humans
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Mitochondria / drug effects*
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Zalcitabine / toxicity
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Zidovudine / toxicity
Substances
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Antiviral Agents
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DNA, Mitochondrial
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Arabinofuranosyluracil
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Zidovudine
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fialuridine
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Zalcitabine
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DNA-Directed DNA Polymerase
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Didanosine