Objective: To determine the kinetics of azithromycin in cervical mucus and plasma.
Subjects and methods: Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose.
Results: In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14.
Conclusion: The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.