One of the most prevalent sexually transmitted diseases is genital human papillomavirus (HPV) infection. Because of its potentially serious consequences for women, HPV infection is receiving a significant amount of attention from researchers and clinicians. We summarize the research and clinical literature on HPV infection. The nature of the virus, the prevalence of HPV infection, and modes of transmission are discussed. Both the physiological and psychological consequences of the infection are explored. Perspectives on treatment are examined, and suggestions for psychoeducational interventions are offered.