Inhibition of HIV replication by amino‐sugar derivatives

GWJ Fleet, A Karpas, RA Dwek, LE Fellows… - FEBS …, 1988 - Wiley Online Library
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and
deoxynojirimycin have recently been shown to have potential anti‐HIV activity [(1987) Proc …

6–0-Butanoylcastanospermine (MDL 28,574) inhibits glycoprotein processing and the growth of HIVs

DL Taylor, PS Sunkara, PS Liu, MS Kang, TL Bowlin… - Aids, 1991 - journals.lww.com
Abstract The antiviral activity of 6-0-butanoylcastanospermine (MDL 28,574)[50% inhibitory
concentration (IC50: 1.1 [mu] M)] in JM cells infected with a recent isolate of HIV-1 (GB8) …

Action of Celgosivir (6 O-Butanoyl Castanospermine) against the Pestivirus BVDV: Implications for the Treatment of Hepatitis C

K Whitby, D Taylor, D Patel… - Antiviral Chemistry …, 2004 - journals.sagepub.com
α-Glucosidase I inhibitors have been shown to inhibit the replication of a broad range of
enveloped viruses by preventing the correct folding of their envelope glycoproteins. This …

Persistence of cytomegalovirus in mononuclear cells in peripheral blood from blood donors.

P Stanier, DL Taylor, AD Kitchen, N Wales… - BMJ: British Medical …, 1989 - ncbi.nlm.nih.gov
Human cytomegalovirus infection is common in the general population but generally
remains silent; the risk of disease is greatest in fetuses and the newborn and in …

Naturally occurring pyrrolizidines: Inhibition of α-glucosidase 1 and anti-HIV activity of one stereoisomer

DL Taylor, R Nash, LE Fellows… - Antiviral Chemistry …, 1992 - journals.sagepub.com
Alexine, a naturally occurring pyrrolizidine alkaloid, isolated from Alexa leiopetala, and four
stereoisomers, isolated from Castanospermum australe, were investigated for inhibitory …

Cytomegalovirus and the acquired immunodeficiency syndrome

AS Tyms, DL Taylor, JM Parkin - Journal of Antimicrobial …, 1989 - academic.oup.com
The acquired immunodeficiency syndrome (AIDS) is complex in nature with one major
aetiological factor but with numerous other agents exploiting the immune incompetence …

Isolation and characterization of the fungal metabolite 3-O-methylviridicatin as an inhibitor of tumour necrosis factor α-induced human immunodeficiency virus …

A Heguy, P Cai, P Meyn, D Houck… - Antiviral Chemistry …, 1998 - journals.sagepub.com
The cytokine tumour necrosis factor α (TNF-α) has been shown to play a role in human
immunodeficiency virus (HIV) replication by activating transcription of the provirus in both T …

The effect of oral treatment with 6-O-butanoyl castanospermine (MDL 28,574) in the murine zosteriform model of HSV-1 infection

CG Bridges, SP Ahmed, MS Kang, RJ Nash… - …, 1995 - academic.oup.com
Oral treatment of mice, cutaneously infected with herpes simplex virus type 1 (HSV-1)(strain
SC16), with the α-gluco-sidase 1 inhibitor 6-O-butanoyl castanospermine (MDL 28,574) …

Loss of cytomegalovirus infectivity after treatment with castanospermine or related plant alkaloids correlates with aberrant glycoprotein synthesis

DL Taylor, LE Fellows, GH Farrar, RJ Nash… - Antiviral research, 1988 - Elsevier
Many plants contain polyhydroxyalkaloids which are potent inhibitors of glucosidases,
enzymes involved in oligosaccharide trimming. These are important in determining the final …

Inhibition of alpha-glucosidase I of the glycoprotein-processing enzymes by 6-O-butanoyl castanospermine (MDL 28,574) and its consequences in human …

DL Taylor, MS Kang, TM Brennan… - Antimicrobial agents …, 1994 - Am Soc Microbiol
The 6-O-butanoyl derivative of castanospermine (MDL 28,574) was previously shown to be
approximately 30-fold more potent than the naturally occurring molecule at inhibiting the …