Multiclass HCV resistance to direct‐acting antiviral failure in real‐life patients advocates for tailored second‐line therapies
VC Di Maio, V Cento, I Lenci, M Aragri… - Liver …, 2017 - Wiley Online Library
Abstract Background & Aims Despite the excellent efficacy of direct‐acting antivirals (DAA)
reported in clinical trials, virological failures can occur, often associated with the …
reported in clinical trials, virological failures can occur, often associated with the …
[HTML][HTML] HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors
Background Because of the extreme genetic variability of hepatitis C virus (HCV), we
analyzed whether specific HCV-genotypes are differently prone to develop resistance to …
analyzed whether specific HCV-genotypes are differently prone to develop resistance to …
Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection
V Svicher, V Cento, M Bernassola, M Neumann-Fraune… - Antiviral research, 2012 - Elsevier
Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated
with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis …
with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis …
Reliability and clinical relevance of the HIV-1 drug resistance test in patients with low viremia levels
Background. We evaluated reliability and clinical usefulness of genotypic resistance testing
(GRT) in patients for whom combination antiretroviral therapy (cART) was unsuccessful with …
(GRT) in patients for whom combination antiretroviral therapy (cART) was unsuccessful with …
[HTML][HTML] Characteristics of hepatitis C virus resistance in an international cohort after a decade of direct-acting antivirals
Background & Aims Direct-acting antiviral (DAA) regimens provide a cure in> 95% of
patients with chronic HCV infection. However, in some patients in whom therapy fails …
patients with chronic HCV infection. However, in some patients in whom therapy fails …
Risk of failure in patients with 215 HIV-1 revertants starting their first thymidine analog-containing highly active antiretroviral therapy
M Violin, A Cozzi-Lepri, R Velleca, A Vincenti, S D'Elia… - Aids, 2004 - journals.lww.com
Objective: To investigate the impact of 215 HIV-1 revertants on the risk of virological failure
of the first thymidine analog-containing highly active antiretroviral therapy (HAART). Design …
of the first thymidine analog-containing highly active antiretroviral therapy (HAART). Design …
[HTML][HTML] Prevalence of single and multiple natural NS3, NS5A and NS5B resistance-associated substitutions in hepatitis C virus genotypes 1–4 in Italy
A Bertoli, MC Sorbo, M Aragri, I Lenci, E Teti, E Polilli… - Scientific reports, 2018 - nature.com
Natural resistance-associated substitutions (RASs) are reported with highly variable
prevalence across different HCV genotypes (GTs). Frequency of natural RASs in a large …
prevalence across different HCV genotypes (GTs). Frequency of natural RASs in a large …
Unexpected rise in the circulation of complex HBV variants enriched of HBsAg vaccine-escape mutations in HBV genotype-D: potential impact on HBsAg detection …
L Piermatteo, S D'Anna, A Bertoli… - Emerging Microbes & …, 2023 - Taylor & Francis
Specific HBsAg mutations are known to hamper HBsAg recognition by neutralizing
antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their …
antibodies thus challenging HBV-vaccination efficacy. Nevertheless, information on their …
Failure on voxilaprevir, velpatasvir, sofosbuvir and efficacy of rescue therapy
J Dietz, VC Di Maio, A de Salazar, D Merino… - Journal of …, 2021 - Elsevier
Background & Aims There are limited data on patients with chronic HCV infection in whom
combination voxilaprevir (VOX), velpatasvir (VEL), sofosbuvir (SOF) retreatment fails. Thus …
combination voxilaprevir (VOX), velpatasvir (VEL), sofosbuvir (SOF) retreatment fails. Thus …
Characterization and structural analysis of novel mutations in human immunodeficiency virus type 1 reverse transcriptase involved in the regulation of resistance to …
F Ceccherini-Silberstein, V Svicher, T Sing… - Journal of …, 2007 - Am Soc Microbiol
Resistance to antivirals is a complex and dynamic phenomenon that involves more
mutations than are currently known. Here, we characterize 10 additional mutations (L74V …
mutations than are currently known. Here, we characterize 10 additional mutations (L74V …