Effect of glycosylation on antibody function: implications for genetic engineering

A Wright, SL Morrison - Trends in biotechnology, 1997 - cell.com
Antibodies are able to both bind antigens and trigger the responses that eliminate them from
circulation. All antibodies are glycosylated at conserved positions in their constant regions …

A comparison of in vitro cytotoxicity assays in medical device regulatory studies

X Liu, DP Rodeheaver, JC White, AM Wright… - Regulatory toxicology …, 2018 - Elsevier
Medical device biocompatibility testing is used to evaluate the risk of adverse effects on
tissues from exposure to leachates/extracts. A battery of tests is typically recommended in …

Antibody variable region glycosylation: position effects on antigen binding and carbohydrate structure.

A Wright, M Tao, EA Kabat, SL Morrison - The EMBO journal, 1991 - embopress.org
The presence of N‐linked carbohydrate at Asn58 in the VH of the antigen binding site of an
antibody specific for alpha (1‐‐‐‐6) dextran (TKC3. 2.2) increases its affinity for dextran 10 …

[HTML][HTML] A physiologist's view of homeostasis

H Modell, W Cliff, J Michael… - Advances in …, 2015 - journals.physiology.org
Homeostasis is a core concept necessary for understanding the many regulatory
mechanisms in physiology. Claude Bernard originally proposed the concept of the …

Effect of altered CH2-associated carbohydrate structure on the functional properties and in vivo fate of chimeric mouse-human immunoglobulin G1.

A Wright, SL Morrison - The Journal of experimental medicine, 1994 - rupress.org
Immunoglobulin G (IgG) molecules are glycosylated in CH2 at Asn297; the N-linked
carbohydrates attached there have been shown to contribute to antibody (Ab) stability and …

Effect of C2-associated carbohydrate structure on Ig effector function: studies with chimeric mouse-human IgG1 antibodies in glycosylation mutants of Chinese …

A Wright, SL Morrison - The Journal of Immunology, 1998 - journals.aai.org
The complex biantennary oligosaccharide at Asn 297 of IgG is essential for some effector
functions. To investigate the effect of carbohydrate structure on Ab function, we have now …

Directed case study method for teaching human anatomy and physiology.

WH Cliff, AW Wright - Advances in physiology education, 1996 - journals.physiology.org
A mastery of human anatomy and physiology requires a familiarity with a vast number of
details about the human body. A directed method of case analysis is described that helps …

In vivo trafficking and catabolism of IgG1 antibodies with Fc associated carbohydrates of differing structure

A Wright, Y Sato, T Okada, KH Chang, T Endo… - …, 2000 - academic.oup.com
We have now produced mouse–human chimeric IgG1 in wild-type Chinese hamster ovary
(CHO) cell lines Pro-5 as well as in the glycosylation mutants Lec 2, Lec 8, and Lec 1 …

A review of the surgical management of heel pressure ulcers in the 21st century

DC Bosanquet, AM Wright, RD White… - International Wound …, 2016 - Wiley Online Library
Heel ulceration, most frequently the result of prolonged pressure because of patient
immobility, can range from the trivial to the life threatening. Whilst the vast majority of heel …

Convenient preparations of t-butyl esters and ethers from t-butanol

SW Wright, DL Hageman, AS Wright, LD McClure - Tetrahedron Letters, 1997 - Elsevier
A one-pot preparation of t-butyl esters and ethers is described that proceeds from the
carboxylic acid or alcohol and t-butanol using only anhydrous magnesium sulfate and …