Machine learning to detect the SINEs of cancer

C Douville, K Lahouel, A Kuo, H Grant… - Science Translational …, 2024 - science.org
We previously described an approach called RealSeqS to evaluate aneuploidy in plasma
cell-free DNA through the amplification of~ 350,000 repeated elements with a single primer …

[HTML][HTML] Using control charts to understand community variation in COVID-19

M Inkelas, C Blair, D Furukawa, VG Manuel… - PLoS …, 2021 - journals.plos.org
Decision-makers need signals for action as the coronavirus disease 2019 (COVID-19)
pandemic progresses. Our aim was to demonstrate a novel use of statistical process control …

Pre-and post-operative plasma glial fibrillary acidic protein levels in patients with newly diagnosed gliomas

H Husain, W Savage, SA Grossman, X Ye… - Journal of neuro …, 2012 - Springer
Therapies that disrupt or repair blood–brain barrier integrity can result in major changes in
MRI images even when the tumor volume remains constant. Thus, a reliable blood-based …

[PDF][PDF] Seq-ing the SINEs of central nervous system tumors in cerebrospinal fluid

C Douville, S Curtis, M Summers, TD Azad… - Cell Reports …, 2023 - cell.com
It is often challenging to distinguish cancerous from non-cancerous lesions in the brain
using conventional diagnostic approaches. We introduce an analytic technique called Real …

Risk of colorectal and other cancers in patients with serrated polyposis

DL Edelstein, M Cruz-Correa, M Soto-Salgado… - Clinical …, 2015 - Elsevier
Patients with serrated polyposis develop multiple colorectal hyperplastic and/or serrated
sessile adenomas/polyps. We investigated the risk of colorectal and other cancers by …

Comparing Factors Associated with Increased Stimulant Use in Relation to HIV Status Using a Machine Learning and Prediction Modeling Approach

CS Blair, M Javanbakht, WS Comulada, R Bolan… - Prevention …, 2023 - Springer
Stimulant use is an important driver of HIV/STI transmission among men who have sex with
men (MSM). Evaluating factors associated with increased stimulant use is critical to inform …

The mutational landscape of spinal chordomas and their sensitive detection using circulating tumor DNA

AK Mattox, B Yang, C Douville, S Lo… - Neuro-Oncology …, 2021 - academic.oup.com
Background Chordomas are the most common primary spinal column malignancy in the
United States. The aim of this study was to determine whether chordomas may be detected …

Brief report: impact of methamphetamine use and rectal STIs on systemic and rectal mucosal inflammation

CS Blair, JA Fulcher, GD Cho… - JAIDS Journal of …, 2023 - journals.lww.com
Background: Methamphetamine (MA) use is associated with sexual risk behavior as well as
systemic and mucosal inflammation, suggesting parallel biological and behavioral …

Brief report: hormonal contraception use and cabotegravir pharmacokinetics in HIV-uninfected women enrolled in HPTN 077

CS Blair, S Li, G Chau, L Cottle… - JAIDS Journal of …, 2020 - journals.lww.com
Objectives: To evaluate whether hormonal contraceptive use among cisgender women is
associated with differences in pharmacokinetic (PK) parameters of a long-acting injectable …

Evaluation of eight plasma proteins as candidate blood-based biomarkers for malignant gliomas

RP Lange, A Everett, P Dulloor, FK Korley… - Cancer …, 2014 - Taylor & Francis
Eight brain-derived proteins were evaluated regarding their potential for further development
as a blood-based biomarker for malignant gliomas. Plasma levels for glial fibrillary acidic …