Human innate immunosenescence: causes and consequences for immunity in old age

A Panda, A Arjona, E Sapey, F Bai, E Fikrig… - Trends in …, 2009 - cell.com
The past decade has seen an explosion in research focusing on innate immunity. Through a
wide range of mechanisms including phagocytosis, intracellular killing and activation of …

West Nile Virus: biology, transmission, and human infection

…, MJ Conway, RR Montgomery, E Fikrig - Clinical microbiology …, 2012 - Am Soc Microbiol
SUMMARY West Nile Virus was introduced into the Western Hemisphere during the late
summer of 1999 and has been causing significant and sometimes severe human diseases …

Tick microbiome: the force within

S Narasimhan, E Fikrig - Trends in parasitology, 2015 - cell.com
Ticks are obligate blood-feeders and serve as vectors of human and livestock pathogens
worldwide. Defining the tick microbiome and deciphering the interactions between the tick …

[HTML][HTML] The IFITM proteins mediate cellular resistance to influenza A H1N1 virus, West Nile virus, and dengue virus

…, BJ Ryan, JL Weyer, L Van Der Weyden, E Fikrig… - Cell, 2009 - cell.com
Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of
respiratory illness. In turn, the host expresses antiviral restriction factors to defend against …

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

…, T Town, L Alexopoulou, JF Anderson, E Fikrig… - Nature medicine, 2004 - nature.com
West Nile virus (WNV), a mosquito-borne single-stranded (ss) RNA flavivirus, causes human
disease of variable severity. We investigated the involvement of Toll-like receptor (Tlr) 3 …

Interleukin (IL)-6 Directs the Differentiation of IL-4–producing CD4+ T Cells

M Rincón, J Anguita, T Nakamura, E Fikrig… - The Journal of …, 1997 - rupress.org
Interleukin (IL)-4 is the most potent factor that causes naive CD4+ T cells to differentiate to
the T helper cell (Th) 2 phenotype, while IL-12 and interferon γ trigger the differentiation of …

[HTML][HTML] Vaccination against Lyme Disease with Recombinant Borrelia burgdorferi Outer-Surface Lipoprotein A with Adjuvant

…, F Meurice, DL Parenti, E Fikrig… - … England Journal of …, 1998 - Mass Medical Soc
Background The risk of acquiring Lyme disease is high in areas in which the disease is
endemic, and the development of a safe and effective vaccine is therefore important …

STAT3 deletion during hematopoiesis causes Crohn's disease-like pathogenesis and lethality: a critical role of STAT3 in innate immunity

…, E Li, JE Craft, ALM Bothwell, E Fikrig… - Proceedings of the …, 2003 - National Acad Sciences
Signal transducer and activator of transcription 3 (STAT3) is a key transcriptional mediator
for many cytokines and is essential for normal embryonic development. We have generated …

[PDF][PDF] The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity

AC Silver, A Arjona, WE Walker, E Fikrig - Immunity, 2012 - cell.com
Circadian rhythms refer to biologic processes that oscillate with a period of∼ 24 hr. These
rhythms are sustained by a molecular clock and provide a temporal matrix that ensures the …

The Lyme disease agent exploits a tick protein to infect the mammalian host

…, FS Kantor, JF Anderson, RA Koski, E Fikrig - Nature, 2005 - nature.com
Abstract The Lyme disease agent, Borrelia burgdorferi, is maintained in a tick–mouse cycle,.
Here we show that B. burgdorferi usurps a tick salivary protein, Salp15 (ref.), to facilitate the …