The development and cultivation of two cell lines from human mesenchymal tumours is
described. Lines 2T and 4T differed from normal human fibroblastic cell strains by showing …

We have previously demonstrated that tumor necrosis factor a (TNF-α), a multifunctional
cytokine mainly produced by activated monocytes, inhibits the ACTH-induced production of …

Sedimentation characteristics of human NK cells in discontinuous Percoll density gradients
were studied. NK activity against the leukaemic cell line K-562 peaked in a single low …

Purpose: The purpose was to evaluate the utility of some bcl-2 family proteins fas and fasL
as predictive indicators for chemotherapy response in advanced breast cancer …

Human natural killer cells cytotoxic against cell-line target cells (NK-CLT) were isolated and
characterized by utilizing adsorption-elution of the effector cells from the K-562 target cells …

Tumor necrosis factor‐alpha (TNF) is a multifunctional cytokine which is cytotoxic for some
tumor cells and transformed cells. The molecular mechanisms which render transformed …

Normal fibroblasts are resistant to the cytotoxic action of tumor necrosis factor (TNF), but are
rendered TNF‐sensitive upon deregulation of c‐Myc. To assess if oncoproteins induce the …

Materials and Methods.-Cell strains: Cell strains WI-26 and WI-38, male and female, re-
spectively, were derived from fetal lung tissue by L. Hayflick according to procedures …

The purpose of this study was to evaluate amplification of topoisomerase IIalpha (TOP2A)
and HER2 genes as predictors of response to chemotherapy in advanced breast cancer …

We studied the cytoskeletal changes in natural killer (NK) cells during conjugate formation,
ie, when NK cells make contact with sensitive vs resistant target cells. F-actin and vinculin …