The Serogroup B Meningococcal Vaccine Bexsero Elicits Antibodies to Neisseria gonorrhoeae

EA Semchenko, A Tan, R Borrow… - Clinical Infectious …, 2019 - academic.oup.com
Abstract Background Neisseria gonorrhoeae and Neisseria meningitidis are closely-related
bacteria that cause a significant global burden of disease. Control of gonorrhoea is …

[HTML][HTML] Characterisation of a Multi-ligand Binding Chemoreceptor CcmL (Tlp3) of Campylobacter jejuni

H Rahman, RM King, LK Shewell… - PLoS …, 2014 - journals.plos.org
Campylobacter jejuni is the leading cause of human gastroenteritis worldwide with over 500
million cases annually. Chemotaxis and motility have been identified as important virulence …

Glycan: glycan interactions: High affinity biomolecular interactions that can mediate binding of pathogenic bacteria to host cells

CJ Day, EN Tran, EA Semchenko… - Proceedings of the …, 2015 - National Acad Sciences
Cells from all domains of life express glycan structures attached to lipids and proteins on
their surface, called glycoconjugates. Cell-to-cell contact mediated by glycan: glycan …

The sweet side of the pathogenic Neisseria: the role of glycan interactions in colonisation and disease

TD Mubaiwa, EA Semchenko… - Pathogens and …, 2017 - academic.oup.com
Glycomics is a rapidly growing field that focuses on the structure and function of
carbohydrates (glycans) in biological systems. Glycan interactions play a major role in …

MetQ of Neisseria gonorrhoeae is a surface-expressed antigen that elicits bactericidal and functional blocking antibodies

EA Semchenko, CJ Day, KL Seib - Infection and immunity, 2017 - Am Soc Microbiol
Neisseria gonorrhoeae, the causative agent of the sexually transmitted infection (STI)
gonorrhea, is a growing public health threat for which a vaccine is urgently needed. We …

[HTML][HTML] Outer membrane vesicle vaccines for Neisseria gonorrhoeae

EA Semchenko, KL Seib - Nature Reviews Urology, 2022 - nature.com
Multidrug-resistant Neisseria gonorrhoeae is a global health problem, and the development
of a vaccine is considered essential for the effective control of gonorrhoea. The use of outer …

[HTML][HTML] The Neisseria gonorrhoeae Vaccine Candidate NHBA Elicits Antibodies That Are Bactericidal, Opsonophagocytic and That Reduce Gonococcal Adherence …

EA Semchenko, CJ Day, KL Seib - Vaccines, 2020 - mdpi.com
Due to the continuing emergence of multidrug resistant strains of Neisseria gonorrhoeae
there is an urgent need for the development of a gonococcal vaccine. We evaluated the …

[HTML][HTML] An open-label randomised controlled trial evaluating the efficacy of a meningococcal serogroup B (4CMenB) vaccine on Neisseria gonorrhoeae infection in …

C Thng, EA Semchenko, I Hughes, M O'Sullivan… - BMC Public Health, 2023 - Springer
Background Gonorrhoea is an ongoing public health concern due to its rising incidence and
the emergence of antibiotic resistance. There are an estimated 82 million new Neisseria …

[HTML][HTML] Variation of chemosensory receptor content of Campylobacter jejuni strains and modulation of receptor gene expression under different in vivo and in vitro …

CJ Day, LE Hartley-Tassell, LK Shewell, RM King… - BMC microbiology, 2012 - Springer
Background Chemotaxis is crucial for the colonisation/infection of hosts with Campylobacter
jejuni. Central to chemotaxis are the group A chemotaxis genes that are responsible for …

[HTML][HTML] The Neisseria gonorrhoeae methionine sulfoxide reductase (MsrA/B) is a surface exposed, immunogenic, vaccine candidate

FEC Jen, EA Semchenko, CJ Day, KL Seib… - Frontiers in …, 2019 - frontiersin.org
Control of the sexually transmitted infection gonorrhea is a major public health challenge,
due to the recent emergence of multidrug resistant strains of Neisseria gonorrhoeae, and …