There are 3 groups of drugs available for the treatment of patients with HIV disease. These
are the nucleoside reverse transcriptase inhibitors ('nucleoside analogues')[zidovudine …

Since its introduction in 1987, zidovudine monotherapy has been the treatment of choice for
patients with HIV infection. Unfortunately it has been established that the beneficial effects of …

An HIV-infected patient in San Francisco with primary syphilis was treated with azithromycin,
but the lesion did not resolve. The authors of this case report confirmed resistance to …

Background. Strain typing is a tool for determining the diversity and epidemiology of
infections. Methods. Treponema pallidum DNA was isolated from 158 patients with syphilis …

Background The European AIDS Clinical Society (EACS) Guidelines cover key aspects of
HIV management with major updates every two years. Guideline highlights The 2019 …

Objective: The most important hepatic enzyme involved in the metabolism of protease
inhibitors is cytochrome P450 3A4 (CYP3A4). Ritonavir (RIT) is a potent inhibitor of CYP3A4 …

Background DNA methylation-based estimators of biological age are reliable biomarkers of
the ageing process. We aimed to investigate a range of epigenetic ageing biomarkers in a …

SEX and sexuality are core dimensions of the human experience and an important
determinant of well-being. An individual's sexual behaviour and sexual health cannot be …

Aims Methadone is predominantly metabolized by cytochrome P450 3A4 and the non
nucleoside reverse transcriptase inhibitor (NNRTI) efavirenz is a recognized inducer of this …

Abstract Background. Antiretrovirals (ARVs) affect bone density and turnover, but their effect
on risk of fractures and osteonecrosis of the femoral head is less understood. We …