A systematic review and meta-analysis of studies evaluating the performance and operational characteristics of dual point-of-care tests for HIV and syphilis

HD Gliddon, RW Peeling, ML Kamb, I Toskin… - Sexually transmitted …, 2017 - sti.bmj.com
Background Mother-to-child transmission (MTCT) of syphilis and HIV continue to be
important yet preventable causes of perinatal and infant morbidity and mortality. Objectives …

Genome‐wide host RNA signatures of infectious diseases: discovery and clinical translation

HD Gliddon, JA Herberg, M Levin, M Kaforou - Immunology, 2018 - Wiley Online Library
The use of whole blood gene expression to derive diagnostic biomarkers capable of
distinguishing between phenotypically similar diseases holds great promise but remains a …

Spin-enhanced nanodiamond biosensing for ultrasensitive diagnostics

BS Miller, L Bezinge, HD Gliddon, D Huang, G Dold… - Nature, 2020 - nature.com
The quantum spin properties of nitrogen-vacancy defects in diamond enable diverse
applications in quantum computing and communications. However, fluorescent …

A rapid drug resistance genotyping workflow for Mycobacterium tuberculosis, using targeted isothermal amplification and nanopore sequencing

HD Gliddon, D Frampton, V Munsamy… - Microbiology …, 2021 - Am Soc Microbiol
Phenotypic drug susceptibility testing (DST) for tuberculosis (TB) requires weeks to yield
results. Although molecular tests rapidly detect drug resistance-associated mutations …

[HTML][HTML] Identification of reduced host transcriptomic signatures for tuberculosis disease and digital PCR-based validation and quantification

HD Gliddon, M Kaforou, M Alikian, B Eley… - Frontiers in …, 2021 - frontiersin.org
Recently, host whole blood gene expression signatures have been identified for diagnosis
of tuberculosis (TB). Absolute quantification of the concentrations of signature transcripts in …

[HTML][HTML] Clinic-based evaluation study of the diagnostic accuracy of a dual rapid test for the screening of HIV and syphilis in pregnant women in Nigeria

I Olugbenga, O Taiwo, M Laverty, E Ngige, C Anyaike… - PLoS …, 2018 - journals.plos.org
Background Screening pregnant women for HIV and syphilis is recommended by WHO in
order to reduce mother-to-child transmission. We evaluated the field performance, feasibility …

[HTML][HTML] Has the HCV cascade of care changed among people who inject drugs in England since the introduction of direct-acting antivirals?

HD Gliddon, Z Ward, E Heinsbroek, S Croxford… - International Journal of …, 2024 - Elsevier
Abstract Background In England, over 80% of those with hepatitis C virus (HCV) infection
have injected drugs. We quantified the HCV cascade of care (CoC) among people who …

A sputum sample processing method for community and mobile tuberculosis diagnosis using the Xpert MTB/RIF assay

HD Gliddon, RJ Shorten, AC Hayward… - ERJ Open …, 2019 - Eur Respiratory Soc
Tuberculosis (TB) remains a global public health emergency and claims the lives of more
people annually than any other infectious disease. TB disproportionately affects people …

Current attitudes towards HIV viral load self-testing: thematic analysis of a consultation with potential end-users

HD Gliddon, RA McKendry, J Gibbs - medRxiv, 2021 - medrxiv.org
Background HIV viral load (VL) is key to monitoring response to antiretroviral therapy. A
number of point-of-care HIV VL tests are in development. These tests could be repurposed …

Towards a future of rapid, low-cost, multiplexed detection of antimicrobial resistance markers for tuberculosis and other pathogens

BS Miller, HD Gliddon, RA McKendry - Clinical Chemistry, 2019 - academic.oup.com
By 2050, antimicrobial resistance (AMR) 3 will put an estimated 10 million lives at risk each
year (1). The discovery of new antibiotics has slowed in recent years, and the prospect of a …