Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns

BMN Kagina, B Abel, TJ Scriba, EJ Hughes… - American journal of …, 2010 - atsjournals.org
Rationale: Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by
measuring the frequency and cytokine expression profile of T cells. Objectives: We tested …

Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study

L Masson, K Mlisana, F Little, L Werner… - Sexually transmitted …, 2014 - sti.bmj.com
Objectives Sexually transmitted infections (STI) and bacterial vaginosis (BV) cause female
genital tract inflammation. This inflammation, which is often present in the absence of …

Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies

WA Hanekom, J Hughes, M Mavinkurve… - Journal of …, 2004 - Elsevier
We optimized a whole blood intracellular cytokine assay to quantitate the frequency of
specific CD4+ and CD8+ T cells in small volumes of whole blood from infants from …

The effect of bacille Calmette-Guerin vaccine strain and route of administration on induced immune responses in vaccinated infants

V Davids, WA Hanekom, N Mansoor… - Journal of Infectious …, 2006 - academic.oup.com
Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) has variable efficacy
in preventing tuberculosis. Both BCG strain and route of administration have been …

[HTML][HTML] Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression

DJ Delgado-Diaz, B Jesaveluk, JA Hayward, D Tyssen… - Microbiome, 2022 - Springer
Background Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at
reduced risk of acquiring sexually transmitted infections including HIV, but the biological …

In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants

EB Kidzeru, AC Hesseling, JAS Passmore, L Myer… - Aids, 2014 - journals.lww.com
Objective: In sub-Saharan Africa, HIV-exposed uninfected (HEU) infants have higher
morbidity and mortality than HIV-unexposed infants. To evaluate whether immune …

Inflammatory cytokine biomarkers of asymptomatic sexually transmitted infections and vaginal dysbiosis: a multicentre validation study

L Masson, S Barnabas, J Deese, K Lennard… - Sexually transmitted …, 2019 - sti.bmj.com
Objectives Vaginal dysbiosis and STIs are important drivers of the HIV epidemic and
reproductive complications. These conditions remain prevalent, partly because most cases …

Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection

L Masson, KB Arnold, F Little, K Mlisana… - Sexually transmitted …, 2016 - sti.bmj.com
Background Untreated sexually transmitted infections (STIs) and bacterial vaginosis (BV)
cause genital inflammation and increase the risk of HIV infection. WHO-recommended …

[HTML][HTML] Exploring potential of vaginal Lactobacillus isolates from South African women for enhancing treatment for bacterial vaginosis

AU Happel, B Kullin, H Gamieldien, N Wentzel… - PLoS …, 2020 - journals.plos.org
Antibiotics continue to be the standard-of-care for bacterial vaginosis (BV), although
recurrence rates are high. Vaginal probiotics may improve durability of BV treatment …

Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV

SL Barnabas, S Dabee, JAS Passmore… - … journal of STD & …, 2018 - journals.sagepub.com
Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections
(STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence …