Specific T cell frequency and cytokine expression profile do not correlate with protection against tuberculosis after bacillus Calmette-Guerin vaccination of newborns
BMN Kagina, B Abel, TJ Scriba, EJ Hughes… - American journal of …, 2010 - atsjournals.org
Rationale: Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by
measuring the frequency and cytokine expression profile of T cells. Objectives: We tested …
measuring the frequency and cytokine expression profile of T cells. Objectives: We tested …
Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study
Objectives Sexually transmitted infections (STI) and bacterial vaginosis (BV) cause female
genital tract inflammation. This inflammation, which is often present in the absence of …
genital tract inflammation. This inflammation, which is often present in the absence of …
Novel application of a whole blood intracellular cytokine detection assay to quantitate specific T-cell frequency in field studies
WA Hanekom, J Hughes, M Mavinkurve… - Journal of …, 2004 - Elsevier
We optimized a whole blood intracellular cytokine assay to quantitate the frequency of
specific CD4+ and CD8+ T cells in small volumes of whole blood from infants from …
specific CD4+ and CD8+ T cells in small volumes of whole blood from infants from …
The effect of bacille Calmette-Guerin vaccine strain and route of administration on induced immune responses in vaccinated infants
V Davids, WA Hanekom, N Mansoor… - Journal of Infectious …, 2006 - academic.oup.com
Vaccination with Mycobacterium bovis bacille Calmette-Guérin (BCG) has variable efficacy
in preventing tuberculosis. Both BCG strain and route of administration have been …
in preventing tuberculosis. Both BCG strain and route of administration have been …
[HTML][HTML] Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression
DJ Delgado-Diaz, B Jesaveluk, JA Hayward, D Tyssen… - Microbiome, 2022 - Springer
Background Women with a cervicovaginal microbiota dominated by Lactobacillus spp. are at
reduced risk of acquiring sexually transmitted infections including HIV, but the biological …
reduced risk of acquiring sexually transmitted infections including HIV, but the biological …
In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants
Objective: In sub-Saharan Africa, HIV-exposed uninfected (HEU) infants have higher
morbidity and mortality than HIV-unexposed infants. To evaluate whether immune …
morbidity and mortality than HIV-unexposed infants. To evaluate whether immune …
Inflammatory cytokine biomarkers of asymptomatic sexually transmitted infections and vaginal dysbiosis: a multicentre validation study
Objectives Vaginal dysbiosis and STIs are important drivers of the HIV epidemic and
reproductive complications. These conditions remain prevalent, partly because most cases …
reproductive complications. These conditions remain prevalent, partly because most cases …
Inflammatory cytokine biomarkers to identify women with asymptomatic sexually transmitted infections and bacterial vaginosis who are at high risk of HIV infection
Background Untreated sexually transmitted infections (STIs) and bacterial vaginosis (BV)
cause genital inflammation and increase the risk of HIV infection. WHO-recommended …
cause genital inflammation and increase the risk of HIV infection. WHO-recommended …
[HTML][HTML] Exploring potential of vaginal Lactobacillus isolates from South African women for enhancing treatment for bacterial vaginosis
Antibiotics continue to be the standard-of-care for bacterial vaginosis (BV), although
recurrence rates are high. Vaginal probiotics may improve durability of BV treatment …
recurrence rates are high. Vaginal probiotics may improve durability of BV treatment …
Converging epidemics of sexually transmitted infections and bacterial vaginosis in southern African female adolescents at risk of HIV
SL Barnabas, S Dabee, JAS Passmore… - … journal of STD & …, 2018 - journals.sagepub.com
Adolescents in Africa are at high risk for HIV infection, other sexually transmitted infections
(STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence …
(STIs) and bacterial vaginosis (BV). Since behavior and burden of STIs/BV may influence …