Columbia exhibited a number of potential strengths relevant to pandemic preparedness
compared with Ontario: there was better coordination between long-term care, public health …

Background Intimate partner violence (IPV) is a significant health problem that has been
associated with HIV infection in numerous studies. We aimed to systematically review the …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

BACKGROUND: In humans and macaques, a promoter polymorphism that decreases
transcription of the serotonin transporter gene is associated with anxiety. Serotonin …

Background Variation in liability to cannabis use disorder has a strong genetic component
(estimated twin and family heritability about 50–70%) and is associated with negative …

Excessive alcohol use, a major cause of morbidity and mortality, is less well understood than
other addictive disorders. Dopamine release in ventral striatum is a common element of drug …

Traits characteristic of type I and type II alcoholism are thought to relate to dysregulated
central nervous system serotonin functioning. In this review, we discuss variables associated …

In a variety of species, development of attachment to a caregiver is crucial for infant survival
and partly mediated by the endogenous opioids. Functional mu-opioid receptor gene …

Childhood maltreatment has diverse, lifelong impact on morbidity and mortality. The
Childhood Trauma Questionnaire (CTQ) is one of the most commonly used scales to assess …

Background Childhood trauma has been linked with a number of negative outcomes later in
life, including alcohol dependence (AD). Previous studies have suggested a mediating role …