[PDF][PDF] The human tumor atlas network: charting tumor transitions across space and time at single-cell resolution
Crucial transitions in cancer—including tumor initiation, local expansion, metastasis, and
therapeutic resistance—involve complex interactions between cells within the dynamic …
therapeutic resistance—involve complex interactions between cells within the dynamic …
Handheld point-of-care ultrasound probes: the new generation of POCUS
Y Baribeau, A Sharkey, O Chaudhary, S Krumm… - Journal of cardiothoracic …, 2020 - Elsevier
Recent advances in ultrasound technology have made ultrasound equipment more
versatile, portable, and accessible than ever. Modern handheld, ultra-portable ultrasound …
versatile, portable, and accessible than ever. Modern handheld, ultra-portable ultrasound …
Efficacy and safety of therapeutic-dose heparin vs standard prophylactic or intermediate-dose heparins for thromboprophylaxis in high-risk hospitalized patients with …
AC Spyropoulos, M Goldin, D Giannis… - JAMA internal …, 2021 - jamanetwork.com
Importance Hospitalized patients with COVID-19 are at risk for venous and arterial
thromboembolism and death. Optimal thromboprophylaxis dosing in high-risk patients is …
thromboembolism and death. Optimal thromboprophylaxis dosing in high-risk patients is …
[PDF][PDF] Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors
S Xu, O Chaudhary, P Rodríguez-Morales, X Sun… - Immunity, 2021 - cell.com
A common metabolic alteration in the tumor microenvironment (TME) is lipid accumulation, a
feature associated with immune dysfunction. Here, we examined how CD8+ tumor infiltrating …
feature associated with immune dysfunction. Here, we examined how CD8+ tumor infiltrating …
[PDF][PDF] Emergence of a high-plasticity cell state during lung cancer evolution
Tumor evolution from a single cell into a malignant, heterogeneous tissue remains poorly
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …
understood. Here, we profile single-cell transcriptomes of genetically engineered mouse …
[PDF][PDF] Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Small cell lung cancer (SCLC) is an aggressive malignancy that includes subtypes defined
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
by differential expression of ASCL1, NEUROD1, and POU2F3 (SCLC-A,-N, and-P …
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
…, J Choi, J LaClair, KE Lawrence, O Chaudhary… - Science, 2022 - science.org
Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the
molecular mechanisms driving this plasticity remain unclear. Using murine organoid and …
molecular mechanisms driving this plasticity remain unclear. Using murine organoid and …
The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion
CD8+ T cells are essential components of the immune response against viral infections and
tumours, and are capable of eliminating infected and cancerous cells. However, when the …
tumours, and are capable of eliminating infected and cancerous cells. However, when the …
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis
The response to tumor-initiating inflammatory and genetic insults can vary among
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …
morphologically indistinguishable cells, suggesting as yet uncharacterized roles for …
Regenerative potential of prostate luminal cells revealed by single-cell analysis
Androgen deprivation is the cornerstone of prostate cancer treatment. It results in involution
of the normal gland to~ 90% of its original size because of the loss of luminal cells. The …
of the normal gland to~ 90% of its original size because of the loss of luminal cells. The …