User profiles for "author:Philip D Butcher"

Philip D Butcher

Professor St George's University of London
Verified email at sgul.ac.uk
Cited by 13988

[HTML][HTML] Clinical use of whole genome sequencing for Mycobacterium tuberculosis

AA Witney, CA Cosgrove, A Arnold, J Hinds, NG Stoker… - BMC medicine, 2016 - Springer
Drug-resistant tuberculosis (TB) remains a major challenge to global health and to
healthcare in the UK. In 2014, a total of 6,520 cases of TB were recorded in England, of …

Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages: Insights into the Phagosomal Environment

D Schnappinger, S Ehrt, MI Voskuil, Y Liu… - The Journal of …, 2003 - rupress.org
Little is known about the biochemical environment in phagosomes harboring an infectious
agent. To assess the state of this organelle we captured the transcriptional responses of …

[HTML][HTML] High-dose rifapentine with moxifloxacin for pulmonary tuberculosis

A Jindani, TS Harrison, AJ Nunn… - … England Journal of …, 2014 - Mass Medical Soc
Background Tuberculosis regimens that are shorter and simpler than the current 6-month
daily regimen are needed. Methods We randomly assigned patients with newly diagnosed …

[HTML][HTML] Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum

NJ Garton, SJ Waddell, AL Sherratt, SM Lee… - PLoS …, 2008 - journals.plos.org
Background Tuberculous sputum provides a sample of bacilli that must be eliminated by
chemotherapy and that may go on to transmit infection. A preliminary observation that …

Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays

GR Stewart, L Wernisch, R Stabler… - …, 2002 - microbiologyresearch.org
Regulation of the expression of heat-shock proteins plays an important role in the
pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves …

Dissection of ESAT-6 System 1 of Mycobacterium tuberculosis and Impact on Immunogenicity and Virulence

P Brodin, L Majlessi, L Marsollier… - Infection and …, 2006 - Am Soc Microbiol
The dedicated secretion system ESX-1 of Mycobacterium tuberculosis encoded by the
extended RD1 region (extRD1) assures export of the ESAT-6 protein and its partner, the 10 …

Microarrays Reveal that Each of the Ten Dominant Lineages of Staphylococcus aureus Has a Unique Combination of Surface-Associated and Regulatory Genes

JA Lindsay, CE Moore, NP Day, SJ Peacock… - Journal of …, 2006 - Am Soc Microbiol
Staphylococcus aureus is the most common cause of hospital-acquired infection. In healthy
hosts outside of the health care setting, S. aureus is a frequent colonizer of the human nose …

Whole genome comparison of Campylobacter jejuni human isolates using a low-cost microarray reveals extensive genetic diversity

N Dorrell, JA Mangan, KG Laing, J Hinds… - Genome …, 2001 - genome.cshlp.org
Campylobacter jejuni is the leading cause of bacterial food-borne diarrhoeal disease
throughout the world, and yet is still a poorly understood pathogen. Whole genome …

[PDF][PDF] Mycobacterial P1-type ATPases mediate resistance to zinc poisoning in human macrophages

H Botella, P Peyron, F Levillain, R Poincloux… - Cell host & …, 2011 - cell.com
Mycobacterium tuberculosis thrives within macrophages by residing in phagosomes and
preventing them from maturing and fusing with lysosomes. A parallel transcriptional survey …

Stationary phase gene expression of Mycobacterium tuberculosis following a progressive nutrient depletion: a model for persistent organisms?

T Hampshire, S Soneji, J Bacon, BW James, J Hinds… - Tuberculosis, 2004 - Elsevier
The majority of individuals infected with TB develop a latent infection, in which organisms
survive within the body while evading the host immune system. Such persistent bacilli are …