Global and regional molecular epidemiology of HIV-1, 1990–2015: a systematic review, global survey, and trend analysis
J Hemelaar, R Elangovan, J Yun… - The Lancet infectious …, 2019 - thelancet.com
Background Global genetic diversity of HIV-1 is a major challenge to the development of HIV
vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and …
vaccines. We aimed to estimate the regional and global distribution of HIV-1 subtypes and …
[HTML][HTML] HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and …
RK Gupta, J Gregson, N Parkin… - The Lancet infectious …, 2018 - thelancet.com
Background Pretreatment drug resistance in people initiating or re-initiating antiretroviral
therapy (ART) containing non-nucleoside reverse transcriptase inhibitors (NNRTIs) might …
therapy (ART) containing non-nucleoside reverse transcriptase inhibitors (NNRTIs) might …
[HTML][HTML] HIV subtype diversity worldwide
N Bbosa, P Kaleebu, D Ssemwanga - Current Opinion in HIV and …, 2019 - journals.lww.com
The dynamic change in HIV subtype distribution presents future challenges for diagnosis,
treatment and vaccine design and development. An increase in recombinant viruses …
treatment and vaccine design and development. An increase in recombinant viruses …
Common variants associated with plasma triglycerides and risk for coronary artery disease
Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary …
epidemiological studies, increased triglyceride levels correlate with higher risk for coronary …
[HTML][HTML] The African genome variation project shapes medical genetics in Africa
Given the importance of Africa to studies of human origins and disease susceptibility,
detailed characterization of African genetic diversity is needed. The African Genome …
detailed characterization of African genetic diversity is needed. The African Genome …
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
P Zanoni, SA Khetarpal, DB Larach… - Science, 2016 - science.org
Scavenger receptor BI (SR-BI) is the major receptor for high-density lipoprotein (HDL)
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a …
cholesterol (HDL-C). In humans, high amounts of HDL-C in plasma are associated with a …
Emergence of new SARS-CoV-2 Variant of Concern Omicron (B. 1.1. 529)-highlights Africa's research capabilities, but exposes major knowledge gaps, inequities of …
E Petersen, F Ntoumi, DS Hui, A Abubakar… - International Journal of …, 2022 - ijidonline.com
Nearly two years since the start of the SARS-CoV-2 pandemic, which has caused over 5
million deaths, the world continues to be on high COVID-19 alert. The World Health …
million deaths, the world continues to be on high COVID-19 alert. The World Health …
Effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on disease progression in a large cohort of HIV-1—positive persons in Uganda
P Kaleebu, N French, C Mahe, D Yirrell… - The Journal of …, 2002 - academic.oup.com
The effect of human immunodeficiency virus (HIV) type 1 envelope subtypes A and D on
disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 …
disease progression was investigated in 1045 adults in Uganda. At enrollment and every 6 …
[HTML][HTML] Geographic and temporal trends in the molecular epidemiology and genetic mechanisms of transmitted HIV-1 drug resistance: an individual-patient-and …
Background Regional and subtype-specific mutational patterns of HIV-1 transmitted drug
resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines …
resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines …
[HTML][HTML] Global epidemiology of drug resistance after failure of WHO recommended first-line regimens for adult HIV-1 infection: a multicentre retrospective cohort study
J Gregson, M Tang, N Ndembi, RL Hamers… - The Lancet infectious …, 2016 - thelancet.com
Background Antiretroviral therapy (ART) is crucial for controlling HIV-1 infection through
wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir …
wide-scale treatment as prevention and pre-exposure prophylaxis (PrEP). Potent tenofovir …