User profiles for "author:R K Lau"

Rebecca K Lau

UC San Diego
Verified email at ucsd.edu
Cited by 1298

An E1–E2 fusion protein primes antiviral immune signalling in bacteria

HE Ledvina, Q Ye, Y Gu, AE Sullivan, Y Quan, RK Lau… - Nature, 2023 - nature.com
In all organisms, innate immune pathways sense infection and rapidly activate potent
immune responses while avoiding inappropriate activation (autoimmunity). In humans, the …

[PDF][PDF] Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity

RK Lau, Q Ye, EA Birkholz, KR Berg, L Patel… - Molecular cell, 2020 - cell.com
Bacteria possess an array of defenses against foreign invaders, including a broadly
distributed bacteriophage defense system termed CBASS (cyclic oligonucleotide-based anti …

[PDF][PDF] HORMA domain proteins and a Trip13-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity

Q Ye, RK Lau, IT Mathews, EA Birkholz, JD Watrous… - Molecular cell, 2020 - cell.com
Bacteria are continually challenged by foreign invaders, including bacteriophages, and have
evolved a variety of defenses against these invaders. Here, we describe the structural and …

Control of bacterial immune signaling by a WYL domain transcription factor

CL Blankenchip, JV Nguyen, RK Lau, Q Ye… - Nucleic acids …, 2022 - academic.oup.com
Bacteria use diverse immune systems to defend themselves from ubiquitous viruses termed
bacteriophages (phages). Many anti-phage systems function by abortive infection to kill a …

A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage

RK Lau, E Enustun, Y Gu, JV Nguyen… - The EMBO …, 2022 - embopress.org
To protect themselves from the constant threat of bacteriophage (phage) infection, bacteria
have evolved diverse immune systems including restriction‐modification, CRISPR‐Cas, and …

Viral mumps: increasing occurrences in the vaccinated population

RK Lau, MD Turner - Oral Surgery, Oral Medicine, Oral Pathology and Oral …, 2019 - Elsevier
Before the introduction of the vaccine, mumps was the most common salivary gland disease
and was one of the most common infectious diseases in children globally. Following the …

[HTML][HTML] Dynamic substrate preferences predict metabolic properties of a simple microbial consortium

O Erbilgin, BP Bowen, SM Kosina, S Jenkins, RK Lau… - BMC …, 2017 - Springer
Background Mixed cultures of different microbial species are increasingly being used to
carry out a specific biochemical function in lieu of engineering a single microbe to do the …

[HTML][HTML] Web of microbes (WoM): a curated microbial exometabolomics database for linking chemistry and microbes

SM Kosina, AM Greiner, RK Lau, S Jenkins, R Baran… - BMC microbiology, 2018 - Springer
Background As microbiome research becomes increasingly prevalent in the fields of human
health, agriculture and biotechnology, there exists a need for a resource to better link …

cGASylation by a bacterial E1-E2 fusion protein primes antiviral immune signaling

HE Ledvina, Q Ye, Y Gu, Y Quan, RK Lau, H Zhou… - BioRxiv, 2022 - biorxiv.org
In all organisms, innate immune pathways sense viral infection and rapidly activate potent
immune responses while maintaining a high degree of specificity to prevent inappropriate …

Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates

JM Olson, CJ Evans, KT Ngo, HJ Kim… - G3: Genes …, 2019 - academic.oup.com
A variety of genetic techniques have been devised to determine cell lineage relationships
during tissue development. Some of these systems monitor cell lineages spatially and/or …