Current status of antivirals and druggable targets of SARS CoV-2 and other human pathogenic coronaviruses

A Artese, V Svicher, G Costa, R Salpini… - Drug Resistance …, 2020 - Elsevier
Coronaviridae is a peculiar viral family, with a very large RNA genome and characteristic
appearance, endowed with remarkable tendency to transfer from animals to humans. Since …

[PDF][PDF] Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression

R Salpini, L Colagrossi, MC Bellocchi, M Surdo… - …, 2015 - Wiley Online Library
Hepatitis B virus (HBV) reactivation during immunosuppression can lead to severe acute
hepatitis, fulminant liver failure, and death. Here, we investigated hepatitis B surface antigen …

Update on SARS-CoV-2 omicron variant of concern and its peculiar mutational profile

M Alkhatib, R Salpini, L Carioti, FA Ambrosio… - Microbiology …, 2022 - Am Soc Microbiol
The process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genetic
diversification is still ongoing and has very recently led to the emergence of a new variant of …

[HTML][HTML] Hepatitis B virus DNA integration as a novel biomarker of hepatitis B virus-mediated pathogenetic properties and a barrier to the current strategies for hepatitis …

R Salpini, S D'Anna, L Benedetti, L Piermatteo… - Frontiers in …, 2022 - frontiersin.org
Chronic infection with Hepatitis B Virus (HBV) is a major cause of liver-related morbidity and
mortality worldwide. HBV-DNA integration into the human genome is recognized as a …

SARS-CoV-2 variants and their relevant mutational profiles: update summer 2021

M Alkhatib, V Svicher, R Salpini… - Microbiology …, 2021 - Am Soc Microbiol
Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic caused by it,
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been undergoing a …

[HTML][HTML] HCV genotypes are differently prone to the development of resistance to linear and macrocyclic protease inhibitors

V Cento, C Mirabelli, R Salpini, S Dimonte, A Artese… - PloS one, 2012 - journals.plos.org
Background Because of the extreme genetic variability of hepatitis C virus (HCV), we
analyzed whether specific HCV-genotypes are differently prone to develop resistance to …

Novel HBsAg markers tightly correlate with occult HBV infection and strongly affect HBsAg detection

V Svicher, V Cento, M Bernassola, M Neumann-Fraune… - Antiviral research, 2012 - Elsevier
Occult HBV infection (OBI) is a threat for the safety of blood-supply, and has been associated
with the onset of HBV-related hepatocellular carcinoma and lymphomagenesis …

Novel concepts on mechanisms underlying Hepatitis Delta virus persistence and related pathogenesis

R Salpini, S D'Anna, L Piermatteo… - Journal of Viral …, 2022 - Wiley Online Library
Hepatitis Delta virus is the smallest known human virus, exploiting the HBV surface proteins
(HBsAg) for the release of its progeny and de novo entry into hepatocytes. Ever growing …

Reactivation of hepatitis B virus with immune-escape mutations after ocrelizumab treatment for multiple sclerosis

MR Ciardi, M Iannetta, MA Zingaropoli… - Open forum …, 2019 - academic.oup.com
Ocrelizumab is an anti-CD20 monoclonal antibody for the treatment of multiple sclerosis
(MS) that is closely related to rituximab. We describe a case of hepatitis B virus (HBV) …

Whole exome HBV DNA integration is independent of the intrahepatic HBV reservoir in HBeAg-negative chronic hepatitis B

V Svicher, R Salpini, L Piermatteo, L Carioti, A Battisti… - Gut, 2021 - gut.bmj.com
Objective The involvement of HBV DNA integration in promoting hepatocarcinogenesis and
the extent to which the intrahepatic HBV reservoir modulates liver disease progression …