[HTML][HTML] How mental health care should change as a consequence of the COVID-19 pandemic
The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns,
physical distancing, and other containment strategies; and the resulting economic …
physical distancing, and other containment strategies; and the resulting economic …
Mitochondrial DNA and two perspectives on evolutionary genetics
This essay reviews comparative studies of animal mitochondrial DNA (mtDNA), with
emphasis on findings made and ideas developed at Berkeley. It argues that such studies are …
emphasis on findings made and ideas developed at Berkeley. It argues that such studies are …
Protein biomarker discovery and validation: the long and uncertain path to clinical utility
N Rifai, MA Gillette, SA Carr - Nature biotechnology, 2006 - nature.com
Better biomarkers are urgently needed to improve diagnosis, guide molecularly targeted
therapy and monitor activity and therapeutic response across a wide spectrum of disease …
therapy and monitor activity and therapeutic response across a wide spectrum of disease …
[HTML][HTML] Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
T Sakurai, A Amemiya, M Ishii, I Matsuzaki… - Cell, 1998 - cell.com
The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same …
homeostasis. We have identified two novel neuropeptides, both derived from the same …
The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease
J Lamb, ED Crawford, D Peck, JW Modell, IC Blat… - science, 2006 - science.org
To pursue a systematic approach to the discovery of functional connections among
diseases, genetic perturbation, and drug action, we have created the first installment of a …
diseases, genetic perturbation, and drug action, we have created the first installment of a …
Metabolite profiles and the risk of developing diabetes
Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …
specimen (metabolomics). We investigated whether metabolite profiles could predict the …
[HTML][HTML] A mitochondrial protein compendium elucidates complex I disease biology
Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …
human diseases. Identifying all of the proteins resident in this organelle and understanding …
Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell
neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, we …
neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, we …
Proteogenomics connects somatic mutations to signalling in breast cancer
Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
these genetic alterations on the proteomic landscape remain poorly understood. Here we …
Obesity, obstetric complications and cesarean delivery rate–a population-based screening study
JL Weiss, FD Malone, D Emig, RH Ball… - American journal of …, 2004 - Elsevier
OBJECTIVE: This study was undertaken to determine whether obesity is associated with
obstetric complications and cesarean delivery. METHODS: A large prospective multicenter …
obstetric complications and cesarean delivery. METHODS: A large prospective multicenter …