User profiles for "author:S Carr"

Steven A Carr

- Verified email at broad.mit.edu - Cited by 93625

Steven M. Carr

- Verified email at mun.ca - Cited by 3665

[HTML][HTML] How mental health care should change as a consequence of the COVID-19 pandemic

…, M Cannon, CU Correll, L Byrne, S Carr… - The lancet …, 2020 - thelancet.com
The unpredictability and uncertainty of the COVID-19 pandemic; the associated lockdowns,
physical distancing, and other containment strategies; and the resulting economic …

Mitochondrial DNA and two perspectives on evolutionary genetics

AC Wilson, RL Cann, SM Carr, M George… - Biological Journal of …, 1985 - academic.oup.com
This essay reviews comparative studies of animal mitochondrial DNA (mtDNA), with
emphasis on findings made and ideas developed at Berkeley. It argues that such studies are …

Protein biomarker discovery and validation: the long and uncertain path to clinical utility

N Rifai, MA Gillette, SA Carr - Nature biotechnology, 2006 - nature.com
Better biomarkers are urgently needed to improve diagnosis, guide molecularly targeted
therapy and monitor activity and therapeutic response across a wide spectrum of disease …

[HTML][HTML] Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

T Sakurai, A Amemiya, M Ishii, I Matsuzaki… - Cell, 1998 - cell.com
The hypothalamus plays a central role in the integrated control of feeding and energy
homeostasis. We have identified two novel neuropeptides, both derived from the same …

The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease

J Lamb, ED Crawford, D Peck, JW Modell, IC Blat… - science, 2006 - science.org
To pursue a systematic approach to the discovery of functional connections among
diseases, genetic perturbation, and drug action, we have created the first installment of a …

Metabolite profiles and the risk of developing diabetes

TJ Wang, MG Larson, RS Vasan, S Cheng, EP Rhee… - Nature medicine, 2011 - nature.com
Emerging technologies allow the high-throughput profiling of metabolic status from a blood
specimen (metabolomics). We investigated whether metabolite profiles could predict the …

[HTML][HTML] A mitochondrial protein compendium elucidates complex I disease biology

DJ Pagliarini, SE Calvo, B Chang, SA Sheth, SB Vafai… - Cell, 2008 - cell.com
Mitochondria are complex organelles whose dysfunction underlies a broad spectrum of
human diseases. Identifying all of the proteins resident in this organelle and understanding …

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

J Krönke, ND Udeshi, A Narla, P Grauman, SN Hurst… - Science, 2014 - science.org
Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell
neoplasms, but its mechanism of action is unknown. Using quantitative proteomics, we …

Proteogenomics connects somatic mutations to signalling in breast cancer

P Mertins, DR Mani, KV Ruggles, MA Gillette… - Nature, 2016 - nature.com
Somatic mutations have been extensively characterized in breast cancer, but the effects of
these genetic alterations on the proteomic landscape remain poorly understood. Here we …

Obesity, obstetric complications and cesarean delivery rate–a population-based screening study

JL Weiss, FD Malone, D Emig, RH Ball… - American journal of …, 2004 - Elsevier
OBJECTIVE: This study was undertaken to determine whether obesity is associated with
obstetric complications and cesarean delivery. METHODS: A large prospective multicenter …