High-Level Azithromycin Resistance Occurs in Neisseria gonorrhoeae as a Result of a Single Point Mutation in the 23S rRNA Genes

SA Chisholm, J Dave, CA Ison - Antimicrobial agents and …, 2010 - Am Soc Microbiol
High-level azithromycin resistance (AZM-HR), defined as a MIC of≥ 256 mg/liter, emerged
in Neisseria gonorrhoeae in the United Kingdom in 2004. To determine the mechanism of …

Cephalosporin MIC creep among gonococci: time for a pharmacodynamic rethink?

SA Chisholm, JW Mouton, DA Lewis… - Journal of …, 2010 - academic.oup.com
Background Gonorrhoea has been among the easiest infections to cure with antibiotics.
Nevertheless, emerging resistance has driven repeated treatment shifts. Decreased …

[HTML][HTML] Public health surveillance of multidrug-resistant clones of Neisseria gonorrhoeae in Europe: a genomic survey

SR Harris, MJ Cole, G Spiteri… - The Lancet Infectious …, 2018 - thelancet.com
Background Traditional methods for molecular epidemiology of Neisseria gonorrhoeae are
suboptimal. Whole-genome sequencing (WGS) offers ideal resolution to describe population …

[HTML][HTML] Decreased susceptibility to cephalosporins among gonococci: data from the Gonococcal Resistance to Antimicrobials Surveillance Programme (GRASP) in …

CA Ison, K Town, C Obi, S Chisholm… - The Lancet Infectious …, 2013 - thelancet.com
Background Effective treatment of gonorrhoea is fundamental to public health control;
however, the ability of Neisseria gonorrhoeae to successively develop resistance to different …

PCR-Based Diagnosis of Helicobacter pylori Infection and Real-Time Determination of Clarithromycin Resistance Directly from Human Gastric Biopsy Samples

SA Chisholm, RJ Owen, EL Teare… - Journal of clinical …, 2001 - Am Soc Microbiol
ABSTRACT A novel PCR detection assay that amplifies the Helicobacter pylori-specific
vacuolating cytotoxin gene (vacA) and thus enables rapid diagnosis of infection is …

An outbreak of high-level azithromycin resistant Neisseria gonorrhoeae in England

SA Chisholm, J Wilson, S Alexander… - Sexually transmitted …, 2016 - sti.bmj.com
Objectives To investigate a potential outbreak of high-level azithromycin resistant (HL-AziR)
gonococcal infections diagnosed in eight patients attending a sexual health clinic in Leeds …

Emergence of high-level azithromycin resistance in Neisseria gonorrhoeae in England and Wales

SA Chisholm, TJ Neal, AB Alawattegama… - Journal of …, 2009 - academic.oup.com
Objectives This study aimed to investigate the origin of high-level azithromycin resistance
that emerged in isolates of Neisseria gonorrhoeae in England and Wales in 2007, and to …

Helicobacter pylori and Extragastric Diseases – Other Helicobacters

A Gasbarrini, E Carloni, G Gasbarrini… - Helicobacter, 2004 - Wiley Online Library
Reports on Helicobacter pylori and extragastric diseases have almost doubled this year
compared with last year, bearing witness to the persistent scientific interest in this branch of …

An evaluation of gentamicin susceptibility of Neisseria gonorrhoeae isolates in Europe

SA Chisholm, N Quaye, MJ Cole… - Journal of …, 2011 - academic.oup.com
Objectives The emergence of decreased susceptibility to third-generation, extended-
spectrum cephalosporins in Neisseria gonorrhoeae and associated treatment failures …

Frequency and correlates of culture-positive infection with Neisseria gonorrhoeae in England: a review of sentinel surveillance data

H Mohammed, CA Ison, C Obi, S Chisholm… - Sexually Transmitted …, 2015 - sti.bmj.com
Objectives Reference laboratories are increasingly using more sensitive rapid molecular
techniques, such as nucleic acid amplification tests (NAATs), to diagnose infections with …