User profiles for "author:Thomas C Quinn"

Thomas C Quinn, MD, MSc

NIAID, NIH, and JHU
Verified email at jhmi.edu
Cited by 109041

Laboratory medicine in Africa: a barrier to effective health care

CA Petti, CR Polage, TC Quinn… - Clinical Infectious …, 2006 - academic.oup.com
Providing health care in sub-Saharan Africa is a complex problem. Recent reports call for
more resources to assist in the prevention and treatment of infectious diseases that affect …

Better tests, better care: improved diagnostics for infectious diseases

AM Caliendo, DN Gilbert, CC Ginocchio… - Clinical Infectious …, 2013 - academic.oup.com
In this IDSA policy paper, we review the current diagnostic landscape, including unmet
needs and emerging technologies, and assess the challenges to the development and …

The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics

L Corey, A Wald, CL Celum… - JAIDS Journal of Acquired …, 2004 - journals.lww.com
Increasing evidence demonstrates a substantial link between the epidemics of sexually
transmitted HIV-1 and herpes simplex virus (HSV)-2 infection. More than 30 epidemiologic …

[HTML][HTML] Viral load and heterosexual transmission of human immunodeficiency virus type 1

TC Quinn, MJ Wawer, N Sewankambo… - New England journal …, 2000 - Mass Medical Soc
Background and Methods We examined the influence of viral load in relation to other risk
factors for the heterosexual transmission of human immunodeficiency virus type 1 (HIV-1). In …

Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial

RH Gray, G Kigozi, D Serwadda, F Makumbi, S Watya… - The lancet, 2007 - thelancet.com
Background Ecological and observational studies suggest that male circumcision reduces
the risk of HIV acquisition in men. Our aim was to investigate the effect of male circumcision …

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

D Finzi, M Hermankova, T Pierson, LM Carruth, C Buck… - Science, 1997 - science.org
The hypothesis that quiescent CD4+ T lymphocytes carrying proviral DNA provide a
reservoir for human immunodeficiency virus–type 1 (HIV-1) in patients on highly active …

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

D Finzi, J Blankson, JD Siliciano, JB Margolick… - Nature medicine, 1999 - nature.com
Combination therapy for HIV-1 infection can reduce plasma virus to undetectable levels,
indicating that prolonged treatment might eradicate the infection. However, HIV-1 can persist …

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

JD Siliciano, J Kajdas, D Finzi, TC Quinn… - Nature medicine, 2003 - nature.com
Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly
active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is …

Quantification of latent tissue reservoirs and total body viral load in HIV-1 infection

TW Chun, L Carruth, D Finzi, X Shen, JA DiGiuseppe… - Nature, 1997 - nature.com
The capacity of HIV-1 to establish latent infection of CD4+ T cells may allow viral persistence
despite immune responses and antiretroviral therapy. Measurements of infectious virus1, 2 …

Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda

MJ Wawer, RH Gray, NK Sewankambo… - The Journal of …, 2005 - academic.oup.com
Background We estimated rates of human immunodeficiency virus (HIV)–1 transmission per
coital act in HIV-discordant couples by stage of infection in the index partner Methods We …